Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

R Weiskirchen, S Weiskirchen, F Tacke - Molecular aspects of medicine, 2019 - Elsevier
Fibrosis denotes excessive scarring, which exceeds the normal wound healing response to
injury in many tissues. Although the extracellular matrix deposition appears unstructured …

Idiopathic pulmonary fibrosis: pathogenesis and management

G Sgalla, B Iovene, M Calvello, M Ori, F Varone… - Respiratory …, 2018 - Springer
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease
characterized by the aberrant accumulation of fibrotic tissue in the lungs parenchyma …

Idiopathic pulmonary fibrosis (IPF): an overview

SL Barratt, A Creamer, C Hayton… - Journal of clinical …, 2018 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterised by chronic,
progressive scarring of the lungs and the pathological hallmark of usual interstitial …

[HTML][HTML] Post-COVID-19 pulmonary fibrosis

A Mohammadi, I Balan, S Yadav, WF Matos… - Cureus, 2022 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected millions
worldwide with a high mortality rate due to a lack of definitive treatment. Despite having a …

Therapeutic approaches to control tissue repair and fibrosis: Extracellular matrix as a game changer

M Walraven, B Hinz - Matrix Biology, 2018 - Elsevier
Organ fibrosis is characterized by the accumulation of disorganized and stiff extracellular
matrix (ECM) and represents the final stage of several life-threatening diseases. The …

[HTML][HTML] Diagnostic and prognostic biomarkers for chronic fibrosing interstitial lung diseases with a progressive phenotype

Y Inoue, RJ Kaner, J Guiot, TM Maher, S Tomassetti… - Chest, 2020 - Elsevier
Biomarkers have the potential to become central to the clinical evaluation and monitoring of
patients with chronic fibrosing interstitial lung diseases (ILDs) with a progressive phenotype …

[HTML][HTML] Acute exacerbations of progressive-fibrosing interstitial lung diseases

M Kolb, B Bondue, A Pesci, Y Miyazaki… - European …, 2018 - Eur Respiratory Soc
Acute exacerbation of interstitial lung disease (ILD) is associated with a poor prognosis and
high mortality. Numerous studies have documented acute exacerbation in idiopathic …

PAD4 deficiency improves bleomycin-induced neutrophil extracellular traps and fibrosis in mouse lung

M Suzuki, J Ikari, R Anazawa, N Tanaka… - American journal of …, 2020 - atsjournals.org
Excessive release of neutrophil extracellular traps (NETs) has been implicated in several
organ fibrosis, including pulmonary fibrosis. NETs constitute a phenomenon in which …

Sputum exosomes: promising biomarkers for idiopathic pulmonary fibrosis

MS Njock, J Guiot, MA Henket, O Nivelles, M Thiry… - Thorax, 2019 - thorax.bmj.com
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease of
unknown aetiology which leads rapidly to death. As diagnosis of IPF is complex, we aimed …

Exosomal long non-coding RNAs in lung diseases

C Poulet, MS Njock, C Moermans, E Louis… - International journal of …, 2020 - mdpi.com
Within the non-coding genome landscape, long non-coding RNAs (lncRNAs) and their
secretion within exosomes are a window that could further explain the regulation, the …