Parkinson's disease (PD) is a chronic, progressive and second most prevalent neurological
disorder affecting the motor system. Cardinal motor impairment and α-synucleinopathy are …

One-carbon metabolism (OCM) is a network of biochemical reactions delivering one-carbon
units to various biosynthetic pathways. The folate cycle and methionine cycle are the two key …

Elevated levels of SNCA have been implicated in the pathogenesis of Parkinson's disease
(PD), while normal physiological levels of SNCA are needed to maintain neuronal function …

The protein dyshomeostasis is identified as the hallmark of many age-related
neurodegenerative disorders including Parkinson's disease (PD). The diseased brain shows …

Evidence for epigenetic regulation playing a role in Parkinson's disease (PD) is growing,
particularly for DNA methylation. Approximately 90% of PD cases are due to a complex …

It is widely believed that environmental exposures contribute to the vast majority of late-
onset sporadic Parkinson's disease (PD), alone or via interactions with genetic factors. The …

Parkinson's disease (PD) comprises a spectrum of disorders with differing subtypes, the vast
majority of which share Lewy bodies (LB) as a characteristic pathological hallmark. The …

Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

The vitamin folic acid has been recognized as a crucial environmental factor for nervous
system development. From the early fetal stages of the formation of the presumptive spinal …

Abstract The IBDs, Crohn's disease and ulcerative colitis, are chronic inflammatory
conditions of the gastrointestinal tract resulting from an aberrant immune response to enteric …