Interactions between the microbiota and pathogenic bacteria in the gut

AJ Bäumler, V Sperandio - Nature, 2016 - nature.com
The microbiome has an important role in human health. Changes in the microbiota can
confer resistance to or promote infection by pathogenic bacteria. Antibiotics have a profound …

Colonocyte metabolism shapes the gut microbiota

Y Litvak, MX Byndloss, AJ Bäumler - Science, 2018 - science.org
BACKGROUND An imbalance in the colonic microbiota might underlie many human
diseases, but the mechanisms that balance our microbial self during homeostasis have long …

The role of COX-2 in intestinal inflammation and colorectal cancer

D Wang, RN DuBois - Oncogene, 2010 - nature.com
Colorectal cancer (CRC) is a heterogeneous disease, including at least three major forms:
hereditary, sporadic and colitis-associated CRC. A large body of evidence indicates that …

Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment

XY Guo, XJ Liu, JY Hao - Journal of digestive diseases, 2020 - Wiley Online Library
Gut microbiota constitute the largest reservoir of the human microbiome and are an
abundant and stable ecosystem—based on its diversity, complexity, redundancy, and host …

The dynamics of gut‐associated microbial communities during inflammation

SE Winter, CA Lopez, AJ Bäumler - EMBO reports, 2013 - embopress.org
Our intestine is host to a large microbial community (microbiota) that educates the immune
system and confers niche protection. Profiling of the gut‐associated microbial community …

A designed whole-cell biosensor for live diagnosis of gut inflammation through nitrate sensing

SG Woo, SJ Moon, SK Kim, TH Kim, HS Lim… - Biosensors and …, 2020 - Elsevier
Microbes reprogrammed using advanced genetic circuits are envisaged as emerging living
diagnostics for a wide range of diseases and play key roles in regulating gut microbiota to …

Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis

F Borrelli, G Aviello, B Romano, P Orlando… - Journal of molecular …, 2009 - Springer
Inflammatory bowel disease affects millions of individuals; nevertheless, pharmacological
treatment is disappointingly unsatisfactory. Cannabidiol, a safe and non-psychotropic …

A Combination of Polymethoxyflavones from Citrus sinensis and Prenylflavonoids from Humulus lupulus Counteracts IL-1β-Induced Differentiated Caco-2 Cells …

I Restivo, MG Basilicata, IC Giardina, A Massaro… - Antioxidants, 2023 - mdpi.com
We here investigated the anti-inflammatory activity of a polymethoxylated flavone-containing
fraction (PMFF) from Citrus sinensis and of a prenylflavonoid-containing one (PFF) from …

[HTML][HTML] Intrauterine growth restriction modifies the developmental pattern of intestinal structure, transcriptomic profile, and bacterial colonization in neonatal pigs

R D'Inca, M Kloareg, C Gras-Le Guen… - The Journal of …, 2010 - Elsevier
Neonates with intrauterine growth restriction (IUGR) are prone to suffer from digestive
diseases. Using neonatal pigs with IUGR, we tested the hypothesis that IUGR may induce …

Nitrate, nitrite and nitric oxide reductases: from the last universal common ancestor to modern bacterial pathogens

A Vázquez-Torres, AJ Bäumler - Current opinion in microbiology, 2016 - Elsevier
Highlights•Bacterial cytochromes are conserved throughout evolution for the utilization of
nitrogen oxides and oxygen.•These metalloproteins support cellular bioenergetics by aiding …