Nondestructive techniques in pharmaceutical drug product characterization

S Beg, K Ahirwar, WH Almalki, SS Almujri… - Drug Discovery …, 2024 - Elsevier
Pharmaceutical product development involves multiple steps; therefore, product quality must
be assessed to ensure robustness and acceptance. Raw components, production methods …

Generic chemometric models for metabolite concentration prediction based on Raman spectra

A Yousefi-Darani, O Paquet-Durand, A Von Wrochem… - Sensors, 2022 - mdpi.com
Chemometric models for on-line process monitoring have become well established in
pharmaceutical bioprocesses. The main drawback is the required calibration effort and the …

[HTML][HTML] Soft sensor based on Raman spectroscopy for the in-line monitoring of metabolites and polymer quality in the biomanufacturing of polyhydroxyalkanoates

JMG Alcântara, F Iannacci, M Morbidelli… - Journal of …, 2023 - Elsevier
Polyhydroxyalkanoates (PHA) are among the most promising bio-based alternatives to
conventional petroleum-based plastics. These biodegradable polyesters can in fact be …

[HTML][HTML] Simultaneous prediction of the API concentration and mass gain of film coated tablets using Near-Infrared and Raman spectroscopy and data fusion

B Szabó-Szőcs, M Ficzere, O Péterfi… - International Journal of …, 2025 - Elsevier
This study investigates the simultaneous prediction of active pharmaceutical ingredient (API)
concentration and mass gain in film-coated tablets using Partial Least Squares (PLS) …

The use of novel, rapid analytical tools in the assessment of the stability of tablets—A pilot analysis of expired and unexpired tablets containing nifuroxazide

B Sarecka-Hujar, B Szulc-Musioł, M Meisner, P Duda - Processes, 2022 - mdpi.com
In the analysis of finished pharmaceutical products, numerous innovative analytical
techniques are often used, ie, Raman spectroscopy, scanning electron microscopy …

Determination of Alzheimer's Drugs in a Human Urine Sample by Different Chemometric Methods: Chemometric Determination of Alzheimer's Drugs

G Pekcan - International Journal of Analytical Chemistry, 2024 - Wiley Online Library
In this study, spectrophotometric determination of donepezil and rivastigmine in healthy
human urine samples was carried out by the statistical method. Partial least squares (PLS) …

Optimization of Tablet Coating

P Vinchhi, MM Patel - Optimization of Pharmaceutical Processes, 2022 - Springer
Although being one of the earliest pharmaceutical unit operations, tablet coating is still
extensively employed in pharmaceutical industries. The application ranges from merely …