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Constructing phase separation in polymer gels: Strategies, functions and applications
Over the past decades, there has been a flourishing of phase-separated polymer gels.
Unlike traditional design methods that rely on chemical structure and polymer network …
Unlike traditional design methods that rely on chemical structure and polymer network …
A guide to single-particle tracking
Individual proteins and protein complexes undergo various motion types, including free
diffusion, confinement, subdiffusion and directed motion. Different motion behaviours reflect …
diffusion, confinement, subdiffusion and directed motion. Different motion behaviours reflect …
Biomolecular condensates modulate membrane lipid packing and hydration
Membrane wetting by biomolecular condensates recently emerged as a key phenomenon in
cell biology, playing an important role in a diverse range of processes across different …
cell biology, playing an important role in a diverse range of processes across different …
Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease
Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …
Higher-order transient membrane protein structures
This study shows that five membrane proteins—three GPCRs, an ion channel, and an
enzyme—form self-clusters under natural expression levels in a cardiac-derived cell line …
enzyme—form self-clusters under natural expression levels in a cardiac-derived cell line …
Lipid Peroxidation Drives Liquid–Liquid Phase Separation and Disrupts Raft Protein Partitioning in Biological Membranes
The peroxidation of membrane lipids by free radicals contributes to aging, numerous
diseases, and ferroptosis, an iron-dependent form of cell death. Peroxidation changes the …
diseases, and ferroptosis, an iron-dependent form of cell death. Peroxidation changes the …
Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane
R Shrestha, TS Carpenter, QN Van, C Agamasu… - Communications …, 2024 - nature.com
The oncogene RAS, extensively studied for decades, presents persistent gaps in
understanding, hindering the development of effective therapeutic strategies due to a lack of …
understanding, hindering the development of effective therapeutic strategies due to a lack of …
Domain-targeted membrane partitioning of specific proteins with DNA nanodevices
The cell membrane exhibits a remarkable complexity of lipids and proteins that dynamically
segregate into distinct domains to coordinate various cellular functions. The ability to …
segregate into distinct domains to coordinate various cellular functions. The ability to …
Flotillin-mediated stabilization of unfolded proteins in bacterial membrane microdomains
The function of many bacterial processes depends on the formation of functional membrane
microdomains (FMMs), which resemble the lipid rafts of eukaryotic cells. However, the …
microdomains (FMMs), which resemble the lipid rafts of eukaryotic cells. However, the …
[HTML][HTML] Transient, nano-scale, liquid-like molecular assemblies coming of age
A Kusumi, TA Tsunoyama, KGN Suzuki… - Current Opinion in Cell …, 2024 - Elsevier
This review examines the dynamic mechanisms underlying cellular signaling,
communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on …
communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on …