Constructing phase separation in polymer gels: Strategies, functions and applications

Z Wang, W Qiu, Q Zhang - Progress in Polymer Science, 2024 - Elsevier
Over the past decades, there has been a flourishing of phase-separated polymer gels.
Unlike traditional design methods that rely on chemical structure and polymer network …

A guide to single-particle tracking

F Simon, LE Weiss, S van Teeffelen - Nature Reviews Methods Primers, 2024 - nature.com
Individual proteins and protein complexes undergo various motion types, including free
diffusion, confinement, subdiffusion and directed motion. Different motion behaviours reflect …

Biomolecular condensates modulate membrane lipid packing and hydration

A Mangiarotti, M Siri, NW Tam, Z Zhao… - Nature …, 2023 - nature.com
Membrane wetting by biomolecular condensates recently emerged as a key phenomenon in
cell biology, playing an important role in a diverse range of processes across different …

Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease

GA Pantelopulos, CB Abraham… - Annual Review of …, 2024 - annualreviews.org
Cholesterol has been conjectured to be a modulator of the amyloid cascade, the mechanism
that produces the amyloid-β (Aβ) peptides implicated in the onset of Alzheimer's disease …

Higher-order transient membrane protein structures

Y Zhang, H Mazal, VS Mandala, G Pérez-Mitta… - Proceedings of the …, 2025 - pnas.org
This study shows that five membrane proteins—three GPCRs, an ion channel, and an
enzyme—form self-clusters under natural expression levels in a cardiac-derived cell line …

Lipid Peroxidation Drives Liquid–Liquid Phase Separation and Disrupts Raft Protein Partitioning in Biological Membranes

M Balakrishnan, AK Kenworthy - Journal of the American …, 2024 - ACS Publications
The peroxidation of membrane lipids by free radicals contributes to aging, numerous
diseases, and ferroptosis, an iron-dependent form of cell death. Peroxidation changes the …

Membrane lipids drive formation of KRAS4b-RAF1 RBDCRD nanoclusters on the membrane

R Shrestha, TS Carpenter, QN Van, C Agamasu… - Communications …, 2024 - nature.com
The oncogene RAS, extensively studied for decades, presents persistent gaps in
understanding, hindering the development of effective therapeutic strategies due to a lack of …

Domain-targeted membrane partitioning of specific proteins with DNA nanodevices

YH Ma, Y Zhu, H Wu, Y He, Q Zhang… - Journal of the …, 2024 - ACS Publications
The cell membrane exhibits a remarkable complexity of lipids and proteins that dynamically
segregate into distinct domains to coordinate various cellular functions. The ability to …

Flotillin-mediated stabilization of unfolded proteins in bacterial membrane microdomains

M Ukleja, L Kricks, G Torrens, I Peschiera… - Nature …, 2024 - nature.com
The function of many bacterial processes depends on the formation of functional membrane
microdomains (FMMs), which resemble the lipid rafts of eukaryotic cells. However, the …

[HTML][HTML] Transient, nano-scale, liquid-like molecular assemblies coming of age

A Kusumi, TA Tsunoyama, KGN Suzuki… - Current Opinion in Cell …, 2024 - Elsevier
This review examines the dynamic mechanisms underlying cellular signaling,
communication, and adhesion via transient, nano-scale, liquid-like molecular assemblies on …