Genetics of global gene expression

MV Rockman, L Kruglyak - Nature Reviews Genetics, 2006 - nature.com
A new field of genetic analysis of global gene expression has emerged in recent years,
driven by the realization that traditional techniques of linkage and association analysis can …

Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution

X Su, KD Lane, L **a, JM Sá… - Clinical microbiology …, 2019 - Am Soc Microbiol
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …

PlasmoDB: a functional genomic database for malaria parasites

C Aurrecoechea, J Brestelli, BP Brunk… - Nucleic acids …, 2009 - academic.oup.com
Abstract PlasmoDB (http://PlasmoDB. org) is a functional genomic database for Plasmodium
spp. that provides a resource for data analysis and visualization in a gene-by-gene or …

Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites

AJ Reid, AM Talman, HM Bennett, AR Gomes… - elife, 2018 - elifesciences.org
Single-cell RNA-sequencing is revolutionising our understanding of seemingly
homogeneous cell populations but has not yet been widely applied to single-celled …

New insights into the blood‐stage transcriptome of Plasmodium falciparum using RNA‐Seq

TD Otto, D Wilinski, S Assefa, TM Keane… - Molecular …, 2010 - Wiley Online Library
Recent advances in high‐throughput sequencing present a new opportunity to deeply probe
an organism's transcriptome. In this study, we used Illumina‐based massively parallel …

Malaria− an overview

R Tuteja - The FEBS journal, 2007 - Wiley Online Library
Malaria is caused by protozoan parasites of the genus Plasmodium and is a major cause of
mortality and morbidity worldwide. These parasites have a complex life cycle in their …

21st century natural product research and drug development and traditional medicines

LT Ngo, JI Okogun, WR Folk - Natural product reports, 2013 - pubs.rsc.org
Covering: 1987 to 2013 Natural products and related structures are essential sources of new
pharmaceuticals, because of the immense variety of functionally relevant secondary …

A subset of group A-like var genes encodes the malaria parasite ligands for binding to human brain endothelial cells

A Claessens, Y Adams, A Ghumra… - Proceedings of the …, 2012 - National Acad Sciences
Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum.
The pathology of cerebral malaria is characterized by the accumulation of infected …

Transcriptional variation in the malaria parasite Plasmodium falciparum

N Rovira-Graells, AP Gupta, E Planet… - Genome …, 2012 - genome.cshlp.org
Malaria genetic variation has been extensively characterized, but the level of epigenetic
plasticity remains largely unexplored. Here we provide a comprehensive characterization of …

Molecular evidence for the localization of Plasmodium falciparum immature gametocytes in bone marrow

R Aguilar, A Magallon-Tejada… - Blood, the journal of …, 2014 - ashpublications.org
Plasmodium falciparum immature gametocytes are not observed in peripheral blood.
However, gametocyte stages in organs such as bone marrow have never been assessed by …