Studying protein interaction networks of all proteins in an organism (“interactomes”) remains
one of the major challenges in modern biomedicine. Such information is crucial to …

Biological mass spectrometry (MS) encompasses a range of methods for characterizing
proteins and other biomolecules. MS is uniquely powerful for the structural analysis of …

The identification of protein complexes in protein-protein interaction networks is the most
fundamental and essential problem for revealing the underlying mechanism of biological …

Proteins differentially interact with each other across cellular states and conditions, but an
efficient proteome-wide strategy to monitor them is lacking. We report the application of …

Protein complexes are one most important kind of functional modules for biological
processes in cells. In this regard, their detection is vital for understanding the principle of cell …

Background Most proteins form macromolecular complexes to perform their biological
functions. However, experimentally determined protein complex data, especially of those …

The co-evolution and co-existence of viral pathogens with their hosts for millions of years is
reflected in dynamic virus-host protein-protein interactions (PPIs) that are intrinsic to the …

Cellular processes are typically carried out by protein complexes and functional modules.
Identifying them plays an important role for our attempt to reveal principles of cellular …

Protein complexes are crucial in improving our understanding of the mechanisms employed
by proteins. Various computational algorithms have thus been proposed to detect protein …

The reductionist approach of dissecting biological systems into their constituents has been
successful in the first stage of the molecular biology to elucidate the chemical basis of …