[HTML][HTML] Effect of stromal cells in tumor microenvironment on metastasis initiation
The cellular environment where tumor cells reside is called the tumor microenvironment
(TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM) …
(TME), which consists of borders, blood vessels, lymph vessels, extracellular matrix (ECM) …
Allosteric modulation of class A GPCRs: targets, agents, and emerging concepts
G-protein-coupled receptors (GPCRs) have been tractable drug targets for decades with
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …
over one-third of currently marketed drugs targeting GPCRs. Of these, the class A GPCR …
Nanomaterials targeting tumor associated macrophages for cancer immunotherapy
Tumor-associated macrophages (TAMs) play an important role in regulating tumor growth,
invasion and metastasis, and constitute approximately 50% of tumor mass. TAMs can exist …
invasion and metastasis, and constitute approximately 50% of tumor mass. TAMs can exist …
A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment
The CXC chemokine receptor type 4 (CXCR4) receptor and its ligand, CXCL12, are
overexpressed in various cancers and mediate tumor progression and hypoxia-mediated …
overexpressed in various cancers and mediate tumor progression and hypoxia-mediated …
Biological and Computational Studies of Hydrazone based Transition Metal (II) Complexes
In the chronicles of human history, infectious diseases played a pivotal role, influencing
societies, steering advancements in medicine, and significantly impacting the well‐being of …
societies, steering advancements in medicine, and significantly impacting the well‐being of …
Diverse catalytic systems for nitrogen-heterocycle formation from O-acyl ketoximes
Z Qu, T Tian, GJ Deng, H Huang - Chinese Chemical Letters, 2023 - Elsevier
O-Acyl ketoximes has been proven to be versatile building blocks for practical construction
of N-heterocycles. In the last few years, diverse catalytic systems have been discovered to …
of N-heterocycles. In the last few years, diverse catalytic systems have been discovered to …
1, 2, 3, 4-Tetrahydroisoquinoline (THIQ) as privileged scaffold for anticancer de novo drug design
Introduction: Cancer is a dreadful disorder that is emerging as one of the leading causes of
mortality across the globe. The complex tumor environment, supplemented with drawbacks …
mortality across the globe. The complex tumor environment, supplemented with drawbacks …
Regioselectivity control in the oxidative formal [3+ 2] annulations of ketoxime acetates and tetrohydroisoquinolines
Z Qu, F Zhang, GJ Deng, H Huang - Organic letters, 2019 - ACS Publications
A novel copper-catalyzed oxidative formal [3+ 2] annulations of ketoxime acetates and
tetrohydroisoquinolines for the synthesis of fused pyrazoles and imidazoles has been …
tetrohydroisoquinolines for the synthesis of fused pyrazoles and imidazoles has been …
Study of CXCR4 chemokine receptor inhibitors using QSPR and molecular docking methodologies
CXCR4 is involved in inflammation, cancer metastasis and also HIV-1 entry into immune
host cells. In the present research, it was decided to investigate the efficacy of some CXCR4 …
host cells. In the present research, it was decided to investigate the efficacy of some CXCR4 …
Development and Therapeutic Perspectives of CXCR4 Antagonists for Disease Therapy
J Yang, E Tian, L Chen, Z Liu, Y Ren, W Mao… - European Journal of …, 2024 - Elsevier
Abstract Chemokine receptor 4 (CXCR4) is a subtype receptor protein of the GPCR family
with a seven-transmembrane structure widely distributed in human tissues. CXCR4 is …
with a seven-transmembrane structure widely distributed in human tissues. CXCR4 is …