The sixth edition of the WHO manual for human semen analysis: a critical review and SWOT analysis

F Boitrelle, R Shah, R Saleh, R Henkel, H Kandil… - Life, 2021 - mdpi.com
Semen analysis is the cornerstone of male fertility evaluation with WHO guidelines providing
the basis for procedural standardization and reference values worldwide. The first WHO …

Frequency, morbidity and equity—the case for increased research on male fertility

S Kimmins, RA Anderson, CLR Barratt… - Nature Reviews …, 2024 - nature.com
Currently, most men with infertility cannot be given an aetiology, which reflects a lack of
knowledge around gamete production and how it is affected by genetics and the …

Oxidative stress-associated male infertility: current diagnostic and therapeutic approaches

H Pavuluri, Z Bakhtiary, MK Panner Selvam… - Medicina, 2024 - mdpi.com
Infertility is a prevalent global issue affecting approximately 17.5% of adults, with sole male
factor contributing to 20–30% of cases. Oxidative stress (OS) is a critical factor in male …

Oxidative stress: a comprehensive review of biochemical, molecular, and genetic aspects in the pathogenesis and management of varicocele

R Finelli, K Leisegang, H Kandil… - The World Journal of …, 2021 - pmc.ncbi.nlm.nih.gov
Oxidative stress is a condition due to an imbalance between the concentrations of oxidants
and antioxidants, and it is a well-recognized contributor in several male infertility conditions …

[HTML][HTML] Oxidative stress markers and sperm DNA fragmentation in men recovered from COVID-19

AD Shcherbitskaia, EM Komarova, YP Milyutina… - International journal of …, 2022 - mdpi.com
SARS-CoV-2 negatively affects semen characteristics, impairs various biochemical
processes in seminal fluid and within spermatogenic cells ultimately leading to male fertility …

Oxidative stress biomarkers in male infertility: established methodologies and future perspectives

F Mottola, I Palmieri, M Carannante, A Barretta… - Genes, 2024 - mdpi.com
Male fertility can be affected by oxidative stress (OS), which occurs when an imbalance
between the production of reactive oxygen species (ROS) and the body's ability to neutralize …

[HTML][HTML] Probing the potential mechanism of quercetin and kaempferol against heat stress-induced sertoli cell injury: through integrating network pharmacology and …

DL Liu, SJ Liu, SQ Hu, YC Chen, J Guo - International Journal of …, 2022 - mdpi.com
Quercetin and kaempferol are flavonoids widely present in fruits, vegetables, and medicinal
plants. They have attracted much attention due to their antioxidant, anti-inflammatory …

Antioxidant therapy for infertile couples: A comprehensive review of the current status and consideration of future prospects

R Saleh, H Sallam, MAE Elsuity, S Dutta… - Frontiers in …, 2025 - frontiersin.org
Oxidative stress (OS) is established as a key factor in the etiology of both male and female
infertility, arising from an imbalance between reactive oxygen species (ROS) production and …

Mitochondrial metabolism determines the functional status of human sperm and correlates with semen parameters

P Irigoyen, P Pintos-Polasky… - Frontiers in Cell and …, 2022 - frontiersin.org
The diagnosis of male infertility is based essentially on the patient's medical history and a
standard semen analysis. However, the latter rarely provides information on the causes of a …

Effect of N-acetyl-L-cysteine on testicular tissue in busulfan-induced dysfunction in the male reproductive system

KH Kim, MJ Park, NC Park… - The World Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Purpose This study aimed to evaluate the protective effect of N-acetyl-L-cysteine (NAC) as
an antioxidant on busulfan-induced testicular dysfunction in mice and elucidate its possible …