Synucleinopathies are clinically and pathologically heterogeneous disorders characterized
by pathologic aggregates of α-synuclein in neurons and glia, in the form of Lewy bodies …

Braak's hypothesis has been extremely influential over the last two decades. However,
neuropathological and clinical evidence suggest that the model does not conform to all …

Several studies have confirmed the α-synuclein real-time quaking-induced conversion (RT-
QuIC) assay to have high sensitivity and specificity for Parkinson's disease. However …

Isolated REM sleep behaviour disorder (RBD) is an early-stage α-synucleinopathy in most, if
not all, affected subjects. Detection of pathological α-synuclein in peripheral tissues of …

The diagnosis of Parkinson's disease (PD) relies on the clinical effects of dopamine
deficiency, including bradykinesia, rigidity and tremor, usually manifesting asymmetrically …

Background The role of the gut‐brain axis has been recently highlighted as a major
contributor to Parkinson's disease (PD) physiopathology, with numerous studies …

Synucleinopathies, including Parkinson's disease (PD), dementia with Lewy Bodies (DLB),
and multiple system atrophy (MSA), are characterized by the misfolding and subsequent …

Background The complexity of the pathogenic mechanisms underlying neurodegenerative
disorders such as Parkinson's disease (PD) is attributable to multifactorial changes …

Parkinson's disease (PD) is a common neurodegenerative disorder arising from an interplay
between genetic and environmental risk factors. Studies have suggested that the …

Previous studies that have investigated the potential of in vivo abnormal α‐synuclein
deposits as a pathological biomarker for PD included few participants and reported different …