The neurotrophic factor BDNF is an important regulator for the development of brain circuits,
for synaptic and neuronal network plasticity, as well as for neuroregeneration and …

Autism spectrum disorder (ASD) is a range of neurodevelopmental disorders characterized
by impaired social interaction and communication, and repetitive or restricted behaviors …

Although mTOR signaling is known as a broad regulator of cell growth and proliferation, in
neurons it regulates synaptic transmission, which is thought to be a major mechanism …

Homeostatic synaptic plasticity is a non-Hebbian synaptic mechanism that adjusts synaptic
strength to maintain network stability while achieving optimal information processing. Among …

Inherited peripheral neuropathies (IPNs) represent a broad group of disorders including
Charcot-Marie-Tooth (CMT) neuropathies characterized by defects primarily arising in …

The mechanistic target of rapamycin (also known as mammalian target of
rapamycin)(mTOR)-dependent signaling pathway plays an important role in protein …

Activity-dependent changes in protein expression are critical for neuronal plasticity, a
fundamental process for the processing and storage of information in the brain. Among the …

Gliomas are aggressive neoplasms that diffusely infiltrate the brain and cause neurological
symptoms, including cognitive deficits and seizures. Increased mTOR signaling has been …

Phosphatidic acid (PA) is a signaling lipid involved in the modulation of synaptic structure
and functioning. Based on previous work showing a decreasing PA gradient along the …

Neuronal overexcitability can disrupt synapse formation and strength and elicit synaptic
changes which in turn give rise to neuronal hyperactivity, and eventually overall abnormal …