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Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention
X Zhu, Z Chen, W Shen, G Huang, JM Sedivy… - Signal transduction and …, 2021 - nature.com
Remarkable progress in ageing research has been achieved over the past decades.
General perceptions and experimental evidence pinpoint that the decline of physical …
General perceptions and experimental evidence pinpoint that the decline of physical …
Transcriptional regulation by Nrf2
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …
[HTML][HTML] Sleep loss can cause death through accumulation of reactive oxygen species in the gut
The view that sleep is essential for survival is supported by the ubiquity of this behavior, the
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …
Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
A Loboda, M Damulewicz, E Pyza, A Jozkowicz… - Cellular and molecular …, 2016 - Springer
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not
only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant …
only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant …
Anatomy and Physiology of the Digestive Tract of Drosophila melanogaster
The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …
now recognized as a major source of signals modulating food intake, insulin secretion and …
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
LW Peterson, D Artis - Nature reviews immunology, 2014 - nature.com
The abundance of innate and adaptive immune cells that reside together with trillions of
beneficial commensal microorganisms in the mammalian gastrointestinal tract requires …
beneficial commensal microorganisms in the mammalian gastrointestinal tract requires …
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …
inducible expression of a battery of genes encoding key components of the glutathione …
Oxidative stress response and Nrf2 signaling in aging
Increasing oxidative stress, a major characteristic of aging, has been implicated in a variety
of age-related pathologies. In aging, oxidant production from several sources is increased …
of age-related pathologies. In aging, oxidant production from several sources is increased …
NRF2 signalling in cytoprotection and metabolism
S Murakami, Y Kusano, K Okazaki… - British journal of …, 2023 - Wiley Online Library
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms
against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing …
against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing …