[HTML][HTML] Thymoquinone (2-Isopropyl-5-methyl-1, 4-benzoquinone) as a chemopreventive/anticancer agent: Chemistry and biological effects

A Ahmad, RK Mishra, A Vyawahare, A Kumar… - Saudi Pharmaceutical …, 2019 - Elsevier
Cancer remains the topmost disorder of the mankind and number of cases is unceasingly
growing at unprecedented rates. Although the synthetic anti-cancer compounds still hold the …

Possible therapeutic effects of Nigella sativa and its thymoquinone on COVID-19

MR Khazdair, S Ghafari, M Sadeghi - Pharmaceutical biology, 2021 - Taylor & Francis
Context COVID-19 is a novel coronavirus that causes a severe infection in the respiratory
system. Nigella sativa L.(Ranunculaceae) is an annual flowering plant used traditionally as …

Protective effects of thymoquinone against acrylamide-induced liver, kidney and brain oxidative damage in rats

MM Abdel-Daim, FI Abo El-Ela, FK Alshahrani… - … Science and Pollution …, 2020 - Springer
Acrylamide (AA), an industrial monomer, may cause multi-organ toxicity through induction of
oxidative stress and inflammation. The antioxidant properties of thymoquinone (TQ), an …

Thymoquinone: review of its potential in the treatment of neurological diseases

FH Pottoo, AM Ibrahim, A Alammar, R Alsinan, M Aleid… - Pharmaceuticals, 2022 - mdpi.com
Thymoquinone (TQ) possesses anticonvulsant, antianxiety, antidepressant, and
antipsychotic properties. It could be utilized to treat drug misuse or dependence, and those …

Delivery of oxaliplatin to colorectal cancer cells by folate-targeted UiO-66-NH2

A Hashemzadeh, F Amerizadeh, F Asgharzadeh… - Toxicology and Applied …, 2021 - Elsevier
Oxaliplatin is being used in different malignancies and several side effects are reported for
patients taking Oxaliplatin, including peripheral neuropathy, nausea and vomiting, diarrhea …

[HTML][HTML] Celastrol and thymoquinone alleviate aluminum chloride-induced neurotoxicity: Behavioral psychomotor performance, neurotransmitter level, oxidative …

F Abbas, MA Eladl, M El-Sherbiny, N Abozied… - Biomedicine & …, 2022 - Elsevier
Exposure to aluminum chloride (AlCl 3) induces progressive multiregional
neurodegeneration in animal models by promoting oxidative stress and neuroinflammation …

What animal models can tell us about long-term cognitive dysfunction following sepsis: A systematic review

FF Savi, A de Oliveira, GF de Medeiros… - Neuroscience & …, 2021 - Elsevier
Survivors of sepsis often develop long-term cognitive impairments. This review aimed at
exploring the results of the behavioral tools and tests which have been used to evaluate …

Vitamin D3 attenuates lipopolysaccharide-induced cognitive impairment in rats by inhibiting inflammation and oxidative stress

A Mokhtari-Zaer, M Hosseini, H Salmani, Z Arab… - Life sciences, 2020 - Elsevier
Aims Vitamin D is a well-known endocrine regulator of calcium/phosphate homeostasis and
has been reported as having a wide range of activities that are potentially beneficial for …

Omega-3 fatty acids prevent nicotine withdrawal-induced impairment of learning and memory via affecting oxidative status, inflammatory response, cholinergic activity …

SM Ahmadi-Soleimani, GY Amiry, E Khordad… - Life sciences, 2023 - Elsevier
In the present study, the main objective was to reveal whether treatment by Omega-3 fatty
acids could prevent the adverse effects of adolescent nicotine withdrawal on spatial and …

[HTML][HTML] The role of thymoquinone as a potent antioxidant in ameliorating the neurotoxic effect of sodium arsenate in female rat

RB Kassab, RE El-Hennamy - Egyptian Journal of Basic and Applied …, 2017 - Elsevier
Arsenic is a neurotoxic substance that makes the brain susceptible to free radicals.
Thymoquinone (TQ) is a potent antioxidant extracted from Nigella sativa seeds. It scavenges …