Primary and secondary negative symptoms in schizophrenia

SN Mosolov, PA Yaltonskaya - Frontiers in psychiatry, 2022 - frontiersin.org
The negative symptoms of schizophrenia include volitional (motivational) impairment
manifesting as avolition, anhedonia, social withdrawal, and emotional disorders such as …

Factors associated with loneliness: an umbrella review of observational studies

M Solmi, N Veronese, D Galvano, A Favaro… - Journal of affective …, 2020 - Elsevier
Background Evidence provides inconsistent findings on risk factors and health outcomes
associated with loneliness. The aim of this work was to grade the evidence on risk factors …

The clinical characterization of the patient with primary psychosis aimed at personalization of management

M Maj, J van Os, M De Hert, W Gaebel… - World …, 2021 - Wiley Online Library
The current management of patients with primary psychosis worldwide is often remarkably
stereotyped. In almost all cases an antipsychotic medication is prescribed, with second …

EPA guidance on assessment of negative symptoms in schizophrenia

S Galderisi, A Mucci, S Dollfus, M Nordentoft… - European …, 2021 - cambridge.org
BackgroundDuring the last decades, a renewed interest for negative symptoms (NS) was
brought about by the increased awareness that they interfere severely with real-life …

The relationship between dissociation and symptoms of psychosis: a meta-analysis

E Longden, A Branitsky, A Moskowitz… - Schizophrenia …, 2020 - academic.oup.com
Evidence suggests that dissociation is associated with psychotic experiences, particularly
hallucinations, but also other symptoms. However, until now, symptom-specific relationships …

Avolition as the core negative symptom in schizophrenia: relevance to pharmacological treatment development

GP Strauss, LA Bartolomeo, PD Harvey - npj Schizophrenia, 2021 - nature.com
Negative symptoms have long been considered a core component of schizophrenia.
Modern conceptualizations of the structure of negative symptoms posit that there are at least …

Pathophysiology of negative symptom dimensions of schizophrenia–current developments and implications for treatment

I Bègue, S Kaiser, M Kirschner - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Negative symptoms of schizophrenia comprise a group of severe symptoms contributing to
high disease burden and poor long-term prognosis. Conceptual work has shown that these …

[HTML][HTML] A large European, multicenter, multinational validation study of the Brief Negative Symptom Scale

A Mucci, A Vignapiano, I Bitter, SF Austin… - European …, 2019 - Elsevier
Negative symptoms represent an unmet need of treatment in schizophrenia. Although a
consensus exists on negative symptom construct, and second generation assessment …

A review of negative symptom assessment strategies in youth at clinical high-risk for psychosis

GP Strauss, A Pelletier-Baldelli, KF Visser… - Schizophrenia …, 2020 - Elsevier
Studies attempting to deconstruct the heterogeneity of schizophrenia and the attenuated
psychosis syndrome consistently find that negative symptoms are a core dimension that is …

Updated perspectives on the clinical significance of negative symptoms in patients with schizophrenia

GM Giordano, E Caporusso, P Pezzella… - Expert Review of …, 2022 - Taylor & Francis
Introduction Negative symptoms in schizophrenia are associated with poor response to
available treatments, poor quality of life, and functional outcome. Therefore, they represent a …