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Organic sonosensitizers for sonodynamic therapy: from small molecules and nanoparticles toward clinical development
Sonodynamic therapy (SDT) is a novel noninvasive therapeutic modality that combines low‐
intensity ultrasound and sonosensitizers. Versus photo‐mediated therapy, SDT has the …
intensity ultrasound and sonosensitizers. Versus photo‐mediated therapy, SDT has the …
Applications of focused ultrasound-mediated blood-brain barrier opening
The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
Soft, bioresorbable coolers for reversible conduction block of peripheral nerves
Implantable devices capable of targeted and reversible blocking of peripheral nerve activity
may provide alternatives to opioids for treating pain. Local cooling represents an attractive …
may provide alternatives to opioids for treating pain. Local cooling represents an attractive …
Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound
Electrical stimulation is a fundamental tool in studying neural circuits, treating neurological
diseases, and advancing regenerative medicine. Injectable, free-standing piezoelectric …
diseases, and advancing regenerative medicine. Injectable, free-standing piezoelectric …
Functional ultrasound imaging of human brain activity through an acoustically transparent cranial window
Visualization of human brain activity is crucial for understanding normal and aberrant brain
function. Currently available neural activity recording methods are highly invasive, have low …
function. Currently available neural activity recording methods are highly invasive, have low …
Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification
Ultrasonic neuromodulation has the unique potential to provide non-invasive control of
neural activity in deep brain regions with high spatial precision and without chemical or …
neural activity in deep brain regions with high spatial precision and without chemical or …
Ultrasound technology and biomaterials for precise drug therapy
Advanced ultrasound technology and functional biomaterials can be used to achieve
precision drug therapy in different aspects such as dose, space, and/or time. At present …
precision drug therapy in different aspects such as dose, space, and/or time. At present …
Remote Control of Energy Transformation‐Based Cancer Imaging and Therapy
Cancer treatment requires precise tumor‐specific targeting at specific sites that allows for
high‐resolution diagnostic imaging and long‐term patient‐tailorable cancer therapy; while …
high‐resolution diagnostic imaging and long‐term patient‐tailorable cancer therapy; while …
Ultrasound as a versatile tool for short-and long-term improvement and monitoring of brain function
Treating the brain with focused ultrasound (FUS) at low intensities elicits diverse responses
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …
in neurons, astroglia, and the extracellular matrix. In combination with intravenously injected …
Optogenetics at the presynapse
Optogenetic actuators enable highly precise spatiotemporal interrogation of biological
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …
processes at levels ranging from the subcellular to cells, circuits and behaving organisms …