Cerebrospinal fluid mechanics and its coupling to cerebrovascular dynamics

AA Linninger, K Tangen, CY Hsu… - Annual Review of Fluid …, 2016 - annualreviews.org
Cerebrospinal fluid (CSF) is not stagnant but displays fascinating oscillatory flow patterns
inside the ventricular system and reversing fluid exchange between the cranial vault and …

Intrathecal drug delivery: advances and applications in the management of chronic pain patient

J De Andres, S Hayek, C Perruchoud… - Frontiers in Pain …, 2022 - frontiersin.org
Advances in our understanding of the biology of spinal systems in organizing and defining
the content of exteroceptive information upon which higher centers define the state of the …

MR-Intracranial pressure (ICP): a method to measure intracranial elastance and pressure noninvasively by means of MR imaging: baboon and human study

NJ Alperin, SH Lee, F Loth, PB Raksin, T Lichtor - Radiology, 2000 - pubs.rsna.org
PURPOSE: To develop a noninvasive method for intracranial elastance and intracranial
pressure (ICP) measurement. MATERIALS AND METHODS: Intracranial volume and …

Quantifying the effect of posture on intracranial physiology in humans by MRI flow studies

N Alperin, SH Lee, A Sivaramakrishnan… - Journal of Magnetic …, 2005 - Wiley Online Library
Purpose To quantify the effect of posture on intracranial physiology in humans by MRI, and
demonstrate the relationship between intracranial compliance (ICC) and pressure (ICP), and …

Cerebrospinal fluid flow in the normal and hydrocephalic human brain

AA Linninger, M Xenos, DC Zhu… - IEEE Transactions …, 2007 - ieeexplore.ieee.org
Advances in magnetic resonance (MR) imaging techniques enable the accurate
measurements of cerebrospinal fluid (CSF) flow in the human brain. In addition, image …

Mechanical properties of dura mater from the rat brain and spinal cord

JT Maikos, RAI Elias, DI Shreiber - Journal of neurotrauma, 2008 - liebertpub.com
The dura mater is the outermost and most substantial meningial layer of central nervous
system (CNS) tissue that acts as a protective membrane for the brain and spinal cord. In …

A mathematical model of blood, cerebrospinal fluid and brain dynamics

AA Linninger, M Xenos, B Sweetman… - Journal of mathematical …, 2009 - Springer
Using first principles of fluid and solid mechanics a comprehensive model of human
intracranial dynamics is proposed. Blood, cerebrospinal fluid (CSF) and brain parenchyma …

Dispersion in porous media in oscillatory flow between flat plates: applications to intrathecal, periarterial and paraarterial solute transport in the central nervous system

M Keith Sharp, RO Carare, BA Martin - Fluids and Barriers of the CNS, 2019 - Springer
Background As an alternative to advection, solute transport by shear-augmented dispersion
within oscillatory cerebrospinal fluid flow was investigated in small channels representing …

Mechanically engineered hydrogel scaffolds for axonal growth and angiogenesis after transplantation in spinal cord injury

A Bakshi, O Fisher, T Dagci, BT Himes… - … of Neurosurgery: Spine, 2004 - thejns.org
Object. Spinal cord injury (SCI) is a complex pathological entity, the treatment of which
requires a multipronged approach. One way to integrate different therapeutic strategies for …

CNS wide simulation of flow resistance and drug transport due to spinal microanatomy

KM Tangen, Y Hsu, DC Zhu, AA Linninger - Journal of biomechanics, 2015 - Elsevier
Spinal microstructures are known to substantially affect cerebrospinal fluid patterns, yet their
actual impact on flow resistance has not been quantified. Because the length scale of …