A unique organelle for studying membrane biochemistry is the mitochondrion whose
functionality depends on a coordinated supply of proteins and lipids. Mitochondria are …

β-Barrel outer membrane proteins (OMPs) represent the major proteinaceous component of
the outer membrane (OM) of Gram-negative bacteria. These proteins perform key roles in …

Radiotherapy is one of the most successful cancer therapies. Here the effect of irradiation on
antigen presentation by MHC class I molecules was studied. Cell surface expression of …

Mitochondria contain∼ 1,000 different proteins, most of which are imported from the cytosol.
Two import pathways that direct proteins into the mitochondrial inner membrane and matrix …

Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported
across one or both mitochondrial membranes. There is an amazingly versatile set of …

Abstract About 10% to 15% of the nuclear genes of eukaryotic organisms encode
mitochondrial proteins. These proteins are synthesized in the cytosol and recognized by …

Mitochondria are organelles with a complex architecture. They are bounded by an envelope
consisting of the outer membrane and the inner boundary membrane (IBM). Narrow crista …

The acquisitions of mitochondria and plastids were important events in the evolution of the
eukaryotic cell, supplying it with compartmentalized bioenergetic and biosynthetic factories …

Transmembrane β barrel proteins are folded into the outer membrane (OM) of Gram-
negative bacteria by the β barrel assembly machinery (BAM) via a poorly understood …

The β-barrel assembly machinery (BAM) is a∼ 203 kDa complex of five proteins (BamA–E),
which is essential for viability in E. coli. BAM promotes the folding and insertion of β-barrel …