Cells convey information about their extracellular environment to their core functional
machineries. Studying the capacity of intracellular signaling pathways to transmit information …

Allostery is a fundamental biophysical mechanism that underlies cellular sensing, signaling,
and metabolism. Yet a quantitative understanding of allosteric genotype‐phenotype …

Microbial populations can adapt to adverse environmental conditions either by appropriately
sensing and responding to the changes in their surroundings or by stochastically switching …

As synthetic biology expands and accelerates into real-world applications, methods for
quantitatively and precisely engineering biological function become increasingly relevant …

An efficient approach for topology optimization under uncertainty is presented. Stochastic
reduced order models (SROMs) are leveraged for the modeling and propagation of …

Flow cytometry is commonly used to evaluate the performance of engineered bacteria. With
increasing use of high-throughput experimental methods, there is a need for automated …

Microbial cell culture is one of the most commonly performed protocols for synthetic biology,
and laboratories are increasingly using 96-well plates and laboratory automation systems …

Humoral communication is mediated by complex signaling pathways that are
heterogeneously activated in individual cells. According to Shannon's information theory …

Cell signaling is essential for individual cells to execute various tasks and respond to
changes in their environment. It is carried out via diffusing molecules, whose transport is …

All living cells are sensors of their environment: they sense signals, hormones, cytokines,
and growth factors, among others. Binding of these signals to cell surface receptors initiates …