The emergence of antibiotic resistant bacteria in the healthcare is a serious concern. In the
Healthcare premises precisely intensive care unit are major sources of microbial diversity …

Carbapenem-resistant Pseudomonas aeruginosa is one of the major concerns in clinical
settings impelling a great challenge to antimicrobial therapy for patients with infections …

Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to
discover new antibiotics. To address this challenge, we trained a deep neural network …

The global emergence of multidrug-resistant Gram-negative bacteria is a growing threat to
antibiotic therapy. The chromosomally encoded drug efflux mechanisms that are ubiquitous …

Microorganisms grouped together into spatially-organized communities called biofilms, are
the cause of dramatic chronic infections in plants, animals and humans. In this review, the …

Since the introduction of penicillin, β-lactam antibiotics have been the antimicrobial agents
of choice. Unfortunately, the efficacy of these life-saving antibiotics is significantly threatened …

Gram-negative bacteria characteristically are surrounded by an additional membrane layer,
the outer membrane. Although outer membrane components often play important roles in …

* Corresponding author. are very toxic to gram-positive bacteria (57, 230, 242). In enteric
gram-negative bacteria, which live in the intestinal tract of animals, the outer membrane has …

Gram-negative bacteria tend to be more resistant to lipophilic and amphiphilic inhibitors than
gram-positive bacteria. Such inhibitors include dyes, detergents, free fatty acids, antibiotics …

Quinolones are broad-spectrum antibacterial agents, commonly used in both clinical and
veterinary medicine. Their extensive use has resulted in bacteria rapidly develo** …