The prefrontal cortex (PFC) plays a critical role in the generation and regulation of emotion.
However, we lack an integrative framework for understanding how different emotion-related …

Although anxiety disorders represent a major societal problem demanding new therapeutic
targets, these efforts have languished in the absence of a mechanistic understanding of this …

Fear can be an adaptive emotion that helps defend against potential danger. Classical
conditioning models elegantly describe how animals learn which stimuli in the environment …

Orchestrating appropriate behavioral responses in the face of competing signals that predict
either rewards or threats in the environment is crucial for survival. The basolateral nucleus of …

How sensory information is transformed by learning into adaptive behaviors is a
fundamental question in neuroscience. Studies of auditory fear conditioning have revealed …

Synchronization of spiking activity in neuronal networks is a fundamental process that
enables the precise transmission of information to drive behavioural responses,,. In cortical …

Anxiety often is studied as a stand-alone construct in laboratory models. But in the context of
co** with real-life anxiety, its negative impacts extend beyond aversive feelings and …

Fear expression relies on the coordinated activity of prefrontal and amygdala circuits, yet the
mechanisms allowing long-range network synchronization during fear remain unknown …

Precise spike timing through the coordination and synchronization of neuronal assemblies is
an efficient and flexible coding mechanism for sensory and cognitive processing,,,,,. In …

Numerous animal studies have demonstrated that fear acquisition and expression rely on
the coordinated activity of medial prefrontal cortex (mPFC) and amygdala and that theta …