Malaria is one of the most devastating human infectious diseases caused by Plasmodium
spp. parasites. A search for an effective and safe vaccine is the main challenge for its …

Plasmodium vivax is the main cause of malarial disease in Asia and South America.
Plasmodium vivax infection was thought to be absent in African populations who are Duffy …

Plasmodium vivax is responsible for most of the malaria infections outside Africa and is
currently the predominant malaria parasite in countries under elimination programs. P. vivax …

The absence of the Duffy protein at the surface of erythrocytes was considered for decades
to confer full protection against Plasmodium vivax as this blood group is the receptor for the …

Introduction Plasmodium vivax causes significant public health problems in endemic
regions. A vaccine to prevent disease is critical, considering the rapid spread of drug …

Plasmodium vivax has been largely neglected over the past century, despite a widespread
recognition of its burden across region where it is endemic. The parasite invades …

Highlights•P. vivax has multiple and novel invasion ligand families (PvDBPs, PvRBPs,
PvTRAgs).•PvDBP binds to DARC.•PvRBP2b binds to the reticulocyte-tropic transferrin …

The Plasmodium vivax reticulocyte invasion process is still poorly understood, with only a
few receptor-ligand interactions identified to date. Individuals with the Southeast Asian …

Background Knowledge of the diversity of invasion ligands in malaria parasites in endemic
regions is essential to understand how natural selection influences genetic diversity of these …

Plasmodium vivax transmission occurs throughout the tropics and is an emerging threat in
areas of Plasmodium falciparum decline, causing relapse infections that complicate …