Placing a patient in a state of general anesthesia is crucial for safely and humanely
performing most surgical and many nonsurgical procedures. How anesthetic drugs create …

Nonlinear dynamics and chaos theory have been used in neurophysiology with the aim to
understand the complex brain activity from electroencephalographic (EEG) signals …

We present the main findings of the 5th National Audit Project (NAP5) on accidental
awareness during general anaesthesia (AAGA). Incidences were estimated using reports of …

Summary The Obstetric Anaesthetists' Association and Difficult Airway Society have
developed the first national obstetric guidelines for the safe management of difficult and …

A comprehensive proposal for a conceptual framework for describing conscious experience
in dreams, integrating philosophy of mind, sleep and dream research, and interdisciplinary …

General anesthesia—a pharmacologically induced reversible state of unconsciousness—
enables millions of life-saving procedures. Anesthetics induce unconsciousness in part by …

Understanding the neural basis of consciousness is fundamental to neuroscience research.
Disruptions in cortico-cortical connectivity have been suggested as a primary mechanism of …

In 1996, we published an editorial 'Ketamine, mechanism (s) of action and unusual clinical
uses' in the British Journal of Anaesthesia. 1 In that editorial, we described the …

Intraoperative awareness, with or without recall, continues to be a topic of clinical
significance and neurobiological interest. In this article, we review evidence pertaining to the …

Mechanical ventilation (MV) is the cornerstone of acute respiratory distress syndrome
(ARDS) management. The use of protective ventilation is a priority in this acute phase of …