Analysis of the human genome reveals that approximately a third of all open reading frames
code for proteins that enter the endoplasmic reticulum (ER), demonstrating the importance of …

Disulfide bond formation is probably involved in the biogenesis of approximately one third of
human proteins. A central player in this essential process is protein disulfide isomerase or …

The endoplasmic reticulum (ER) is a highly versatile protein factory that is equipped with
chaperones and folding enzymes essential for protein folding. ER quality control guided by …

Large-scale sequencing of genomes has revealed that most enzyme families include
inactive homologues. These pseudoenzymes are often well conserved, implying a selective …

Immunoprecipitation (IP) uses the specificity of antibodies to isolate target proteins
(antigens) out of complex sample mixtures. Three different approaches for performing IP will …

Abstract Purpose Single nucleotide polymorphisms (SNPs) of the ATP-binding cassette
(ABC) transporter ABCG2 gene have been suggested to be a significant factor in patients' …

Membrane penetration of nonenveloped viruses is a poorly understood process. We have
investigated early stages of this process by studying the conformational change experienced …

The esophageal epithelium is subject to damage from bile acid reflux that promotes normal
tissue injury resulting in the development of Barrett's epithelium. There is a selection …

Background & Aims N 6-methyladenosine (m 6 A), the most prevalent and dynamic
posttranscriptional methylation modification of mammalian mRNA, is involved in various …

Primary congenital hypothyroidism (CH) is the most common endocrine disease in children
and one of the most common preventable causes of both cognitive and motor deficits. CH is …