Review of measurements and imaging of cytochrome-c-oxidase in humans using near-infrared spectroscopy: an update

G Leadley, T Austin, G Bale - Biomedical Optics Express, 2023‏ - opg.optica.org
This review examines advancements in the measurement and imaging of oxidized
cytochrome-c-oxidase (oxCCO) using near-infrared spectroscopy (NIRS) in humans since …

MAESTROS: a multiwavelength time-domain NIRS system to monitor changes in oxygenation and oxidation state of cytochrome-C-oxidase

F Lange, L Dunne, L Hale… - IEEE Journal of Selected …, 2018‏ - ieeexplore.ieee.org
We present a multiwavelength, multichannel, time-domain near-infrared spectroscopy
system named MAESTROS. This instrument can measure absorption and scattering …

Investigating the effect of limited spectral information on NIRS-derived changes in hemoglobin and cytochrome-c-oxidase concentration with a diffusion-based model

G Leadley, RJ Cooper, T Austin, JC Hebden… - Biomedical Optics …, 2024‏ - opg.optica.org
This paper investigates the theoretical capability of near-infrared spectroscopy (NIRS)
systems to accurately measure changes in the oxidation state of cerebral cytochrome-c …

The use of supercontinuum laser sources in biomedical diffuse optics: unlocking the power of multispectral imaging

F Lange, L Giannoni, I Tachtsidis - Applied Sciences, 2021‏ - mdpi.com
Optical techniques based on diffuse optics have been around for decades now and are
making their way into the day-to-day medical applications. Even though the physics …

Time-domain NIRS system based on supercontinuum light source and multi-wavelength detection: validation for tissue oxygenation studies

A Sudakou, F Lange, H Isler, P Lanka… - Biomedical Optics …, 2021‏ - opg.optica.org
We present and validate a multi-wavelength time-domain near-infrared spectroscopy (TD-
NIRS) system that avoids switching wavelengths and instead exploits the full capability of a …

Quantification of cytochrome c oxidase and tissue oxygenation using CW-NIRS in a mouse cerebral cortex

M Hashem, Y Wu, JF Dunn - Biomedical Optics Express, 2021‏ - opg.optica.org
We provide a protocol for measuring the absolute concentration of the oxidized and reduced
state of cytochrome c oxidase (CCO) in the cerebral cortex of mice, using broadband …

Broadband time-resolved multi-channel functional near-infrared spectroscopy system to monitor in vivo physiological changes of human brain activity

F Lange, F Peyrin, B Montcel - Applied optics, 2018‏ - opg.optica.org
We have developed a broadband time-resolved multi-channel near-infrared spectroscopy
system that can monitor the physiological responses of the adult human brain. This system is …

Understanding metabolic responses to forearm arterial occlusion measured with two-channel broadband near-infrared spectroscopy

F Saeed, C Carter, J Kolade… - Journal of Biomedical …, 2024‏ - spiedigitallibrary.org
Significance Broadband near-infrared spectroscopy (bbNIRS) is useful for the quantification
of cerebral metabolism. However, its usefulness has not been explored for broad biomedical …

A spread spectrum approach to time-domain near-infrared diffuse optical imaging using inexpensive optical transceiver modules

KI Papadimitriou, LA Dempsey, JC Hebden… - Biomedical Optics …, 2018‏ - opg.optica.org
We introduce a compact time-domain system for near-infrared spectroscopy using a spread
spectrum technique. The proof-of-concept single channel instrument utilises a low-cost …

Noninvasive Monitoring of Metabolism and Hemodynamics Using Super-Continuum Infrared Spectroscopy of a Cytochrome C Oxidase (SCISCCO) Instrument

MN Islam, T Zhai, A Dobre, CN Meah, I Kovelman… - Applied Sciences, 2022‏ - mdpi.com
We present a novel, noninvasive, super-continuum infrared spectroscopy of cytochrome c
oxidase (SCISCCO) system for simultaneously measuring hemodynamic and metabolic …