How Caenorhabditis elegans Senses Mechanical Stress, Temperature, and Other Physical Stimuli

MB Goodman, P Sengupta - Genetics, 2019 - academic.oup.com
Caenorhabditis elegans lives in a complex habitat in which they routinely experience large
fluctuations in temperature, and encounter physical obstacles that vary in size and …

Microfluidic systems for high-throughput and high-content screening using the nematode Caenorhabditis elegans

M Cornaglia, T Lehnert, MAM Gijs - Lab on a Chip, 2017 - pubs.rsc.org
In a typical high-throughput drug screening (HTS) process, up to millions of chemical
compounds are applied to cells cultured in well plates, aiming to find molecules that exhibit …

Fish-on-a-chip: microfluidics for zebrafish research

F Yang, C Gao, P Wang, GJ Zhang, Z Chen - Lab on a Chip, 2016 - pubs.rsc.org
High-efficiency zebrafish (embryo) handling platforms are crucially needed to facilitate the
deciphering of the increasingly expanding vertebrate–organism model values. However, the …

Microfluidic Approaches for Manipulating, Imaging, and Screening C. elegans

BP Gupta, P Rezai - Micromachines, 2016 - mdpi.com
The nematode C. elegans (worm) is a small invertebrate animal widely used in studies
related to fundamental biological processes, disease modelling, and drug discovery. Due to …

Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics

J Zhang, JH Hartman, C Chen, S Yang, Q Li, Z Tian… - Lab on a Chip, 2020 - pubs.rsc.org
Effectively isolating and categorizing large quantities of Caenorhabditis elegans (C.
elegans) based on different phenotypes is important for most worm research, especially …

Electrotaxis-on-chip to quantify neutrophil migration towards electrochemical gradients

M Moarefian, RV Davalos, MD Burton… - Frontiers in …, 2021 - frontiersin.org
Electric fields are generated in vivo in a variety of physiologic and pathologic settings,
including wound healing and immune response to injuries to epithelial barriers (eg lung …

Studying Parkinson's disease using Caenorhabditis elegans models in microfluidic devices

K Youssef, A Tandon, P Rezai - Integrative Biology, 2019 - academic.oup.com
Parkinson's disease (PD) is a progressive neurological disorder associated with the loss of
dopaminergic neurons (DNs) in the substantia nigra and the widespread accumulation of α …

Microfluidic-Assisted Caenorhabditis elegans Sorting: Current Status and Future Prospects

H Yuan, W Yuan, S Duan, K Jiao, Q Zhang… - Cyborg and Bionic …, 2023 - spj.science.org
Caenorhabditis elegans (C. elegans) has been a popular model organism for several
decades since its first discovery of the huge research potential for modeling human diseases …

Microfluidic Technologies for High Throughput Screening Through Sorting and On-Chip Culture of C. elegans

D Midkiff, A San-Miguel - Molecules, 2019 - mdpi.com
The nematode Caenorhabditis elegans is a powerful model organism that has been widely
used to study molecular biology, cell development, neurobiology, and aging. Despite their …

Stress and timing associated with Caenorhabditis elegans immobilization methods

JR Manjarrez, R Mailler - Heliyon, 2020 - cell.com
Background Caenorhabditis elegans is a model organism used to study gene, protein, and
cell influence on function and behavior. These studies frequently require C. elegans to be …