[HTML][HTML] A combined evolutionary and structural approach to disclose the primary structural determinants essential for proneurotrophins biological functions

S Covaceuszach, LY Peche, PV Konarev… - Computational and …, 2021 - Elsevier
Abstract The neurotrophins, ie, Nerve Growth Factor (NGF), Brain-Derived Neurotrophic
Factor (BDNF), Neurotrophin 3 (NT3) and Neurotrophin 4 (NT4), are known to play a range …

Zinc induced structural changes in the intrinsically disordered BDNF Met prodomain confer synaptic elimination

J Wang, A Anastasia, H Bains, JI Giza, DG Clossey… - Metallomics, 2020 - academic.oup.com
Human brain derived neurotrophic factor (BDNF) encodes a protein product consisting of a
C-terminal mature domain (mature BDNF) and an N-terminal prodomain, which is an …