The allene functionality has participated in one of the most exciting voyages in organic
chemistry, from chemical curiosities to a recurring building block in modern organic …

Conspectus So far, over 150 natural products and pharmaceuticals containing an allene
moiety have been identified. During the last two decades, allenes have also been …

Metal-catalyzed enantioselective construction of the loosening axial allene chirality
spreading over three carbon atoms using a chiral ligand is still a significant challenge. In the …

Chiral allenes are highly valuable as versatile synthetic intermediates and core skeletons of
various functional organic molecules. Despite marked recent advances, the straightforward …

We report the first example of intermolecular allenyl functionalization of alkenes by a radical-
polar crossover process. This reaction leads to homoallenic alcohols and amides with high …

Density functional theory (DFT) calculations have been conducted to study the mechanisms,
substituent effects, and the role of bases in Au-and Cu-catalyzed hydroacylation of terminal …

DFT calculations are carried out to investigate the hydroacylation mechanism based on
copper-catalyzed A 3-coupling tandem reaction of terminal alkynes, aldehydes and amines …

A straightforward, user-friendly, efficient protocol for the one pot, ZnI2-catalyzed allenylation
of terminal alkynes with pyrrolidine and ketones, toward trisubstituted allenes, is described …

Catalytic processes in protecting-group-free syntheses of natural products are fast emerging
towards achieving the goal of efficiency and economy in total synthesis. Present day …

Selectivity control of the reactions of propargylic and/or allenylic radicals remains particularly
elusive. Here, a visible light-mediated Cu-catalyzed protocol for the highly selective …