The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor
growth, analogous to the renewal of healthy tissues, is fueled by small numbers of dedicated …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Cancer is a multi-step process and requires constitutive expression/activation of
transcription factors (TFs) for growth and survival. Many of the TFs reported so far are critical …

Cancer development is a complex process driven by inherited and acquired molecular and
cellular alterations. Prevention is the holy grail of cancer elimination, but making this a reality …

Endometrial cancer (EC) is the most frequent gynecological cancer. In patients with relapsed
and advanced disease, prognosis is still dismal and development of resistance is common …

Immune therapies in acute myeloid leukemia: a focus on monoc... : Current Opinion in
Hematology Immune therapies in acute myeloid leukemia: a focus on monoclonal antibodies …

Individual instances of cancer are primarily a result of a combination of a small number of
genetic mutations (hits). Knowing the number of such mutations is a prerequisite for …

Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. ALL arises
from the malignant transformation of progenitor B-and T-cells in the bone marrow into …

Simple Summary Drug resistance and insensitivity to treatments are the main challenges in
breast cancer therapy. Cancer-associated fibroblasts (CAFs) are heterogeneous stromal …

Quiescence has been observed in stem cells (SCs), including adult SCs and cancer SCs
(CSCs). Conventional chemotherapies mostly target proliferating cancer cells, while the …