Therapeutic inertia in the treatment of hyperglycaemia in patients with type 2 diabetes: a systematic review

K Khunti, MB Gomes, S Pocock… - Diabetes, Obesity …, 2018 - Wiley Online Library
Aims Therapeutic inertia, defined as the failure to initiate or intensify therapy in a timely
manner according to evidence‐based clinical guidelines, is a key reason for uncontrolled …

Identification of barriers to insulin therapy and approaches to overcoming them

D Russell‐Jones, F Pouwer… - Diabetes, Obesity and …, 2018 - Wiley Online Library
Poor glycaemic control in type 2 diabetes (T2D) is a global problem despite the availability
of numerous glucose‐lowering therapies and clear guidelines for T2D management …

Switching to once-weekly insulin icodec versus once-daily insulin degludec in individuals with basal insulin-treated type 2 diabetes (ONWARDS 2): a phase 3a …

A Philis-Tsimikas, M Asong, E Franek, T Jia… - The Lancet Diabetes & …, 2023 - thelancet.com
Background Insulin icodec (icodec) is a once-weekly basal insulin currently under
development. ONWARDS 2 aimed to assess the efficacy and safety of once-weekly icodec …

Switching to once-weekly insulin icodec versus once-daily insulin glargine U100 in type 2 diabetes inadequately controlled on daily basal insulin: a phase 2 …

HS Bajaj, RM Bergenstal, A Christoffersen… - Diabetes …, 2021 - diabetesjournals.org
OBJECTIVE Insulin icodec (icodec) is a novel once-weekly basal insulin analog. This trial
investigated two approaches for switching to icodec versus once-daily insulin glargine 100 …

Clinical inertia, reverse clinical inertia, and medication non-adherence in type 2 diabetes

D Giugliano, MI Maiorino, G Bellastella… - Journal of …, 2019 - Springer
Purpose Clinical inertia and medication non-adherence are thought to contribute largely to
the suboptimal glycemic control in many patients with type 2 diabetes. The present review …

Therapeutic inertia in patients treated with two or more antidiabetics in primary care: F actors predicting intensification of treatment

M Mata‐Cases, J Franch‐Nadal, J Real… - Diabetes, Obesity …, 2018 - Wiley Online Library
Aims To determine the patterns and predictors of treatment intensification in patients with
type 2 diabetes on≥ 2 non‐insulin antidiabetic drugs (NIAD s) and inadequate glycaemic …

Therapeutic inertia and delays in insulin intensification in type 2 diabetes: a literature review

JR Gavin, RM Abaniel, NS Virdi - Diabetes Spectrum, 2023 - diabetesjournals.org
Background Therapeutic inertia leading to delays in insulin initiation or intensification is a
major contributor to lack of optimal diabetes care. This report reviews the literature …

100 years on: the impact of the discovery of insulin on clinical outcomes

JB Buse, MJ Davies, BM Frier… - BMJ Open Diabetes …, 2021 - drc.bmj.com
Throughout history, up to the early part of the 20th century, diabetes has been a devastating
disorder, particularly when diagnosed in childhood when it was usually fatal. Consequently …

Efficacy and safety of once-weekly insulin icodec compared to once-daily insulin g U-100 in patients with type II diabetes: a systematic review and meta-analysis

SZ Saleem, A Fareed, SMM Akhtar, S Farhat… - Diabetology & Metabolic …, 2024 - Springer
Abstract Background//Objective Diabetes affects millions of people globally, despite
treatment options, adherence and other factors pose obstacles. Once-weekly Insulin Icodec …

Factors associated with psychological insulin resistance among patients with type 2 diabetes in China

S Zhang, X Zhang, H Wang, W Fan, X Ma… - Frontiers in …, 2024 - frontiersin.org
Objective The aim of this study was to understand the psychological insulin resistance status
among Chinese patients with type 2 diabetes and investigate its associated factors in these …