Microtubules are one of the major cytoskeletal components of neurons, essential for many
fundamental cellular and developmental processes, such as neuronal migration, polarity …

Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules.
Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells …

Microtubule (MT)–associated protein 7 (MAP7) is a required cofactor for kinesin-1–driven
transport of intracellular cargoes. Using cryo–electron microscopy and single–molecule …

Exome sequencing is an effective strategy for identifying human disease genes. However,
this methodology is difficult in late-onset diseases where limited availability of DNA from …

Transmission electron microscopy (EM) is a versatile technique that can be used to image
biological specimens ranging from intact eukaryotic cells to individual proteins> 150 kDa …

The genetic causes of malformations of cortical development (MCD) remain largely
unknown. Here we report the discovery of multiple pathogenic missense mutations in …

Classical microtubule‐associated proteins (MAPs) were originally identified based on their
co‐purification with microtubules assembled from mammalian brain lysate. They have since …

Kinesin superfamily proteins (KIFs) largely serve as molecular motors on the microtubule
system and transport various cellular proteins, macromolecules, and organelles. These …

Many eukaryotic cells distribute their intracellular components asymmetrically through
regulated active transport driven by molecular motors along microtubule tracks. While …

Advances in the study of brain development over the last decades, especially recent findings
regarding the evolutionary expansion of the human neocortex, and large-scale analyses of …