Neuronal networks consist of different types of neurons that all play their own role in order to
maintain proper network function. The two main types of neurons segregate in excitatory and …

Long-lasting changes of brain function in response to experience rely on diverse forms of
activity-dependent synaptic plasticity. Chief among them are long-term potentiation and long …

Background Genetic factors play a major role in the risk for neurodevelopmental disorders
such as autism spectrum disorders (ASDs) and intellectual disability (ID). The underlying …

Abstract Disrupted-in-Schizophrenia 1 (DISC1) is a gene known as a risk factor for mental
illnesses possibly associated with dopamine impairments. DISC1 is a scaffold protein …

Background Parvalbumin interneuron (PVI) activity synchronizes the medial prefrontal cortex
circuit for normal cognitive function, and its impairment may contribute to schizophrenia (SZ) …

Clinical and pre-clinical evidence has implicated neuregulin 1 (NRG1) as a critical
component in the pathophysiology of schizophrenia. However, the arrival of the genome …

Astrocytes and microglia play critical roles in brain inflammation. Here, we report that
glutathione S-transferases (GSTs), particularly GSTM1, promote proinflammatory signaling …

Schizophrenia (SZ) and autism spectrum disorders (ASD) are characterised by marked
language deficits, but it is not clear how these arise from gene mutations associated with the …

A wide range of Ca 2+-mediated functions are enabled by the dynamic properties of Ca 2+,
all of which are dependent on the endoplasmic reticulum (ER) and mitochondria. Disrupted …

Since the middle of the past century, we have serendipitously come across treatment
regimens that can partially ameliorate psychosis and depression. Nonetheless, the …