Exosomes are well-known key mediators of intercellular communication and contribute to
various physiological and pathological processes. Their biogenesis involves four key steps …

Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Since the discovery of the ubiquitin proteasome system (UPS), the roles of ubiquitinating
and deubiquitinating enzymes (DUBs) have been widely elucidated. The ubiquitination of …

Abstract For many decades, poly (2‐oxazoline) s and poly (2‐oxazine) s, two closely related
families of polymers, have led the life of a rather obscure research topic with only a few …

Simple Summary The ubiquitin-proteasome system regulates multiple facets of protein
homeostasis to modulate signal transduction in numerous biological processes. Not …

Breast cancer has the highest incidence and death rate among cancers in women
worldwide. In particular, metastatic estrogen receptor negative (ER–) breast cancer and …

Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a deubiquitylating enzyme that is
proposed as a potential therapeutic target in neurodegeneration, cancer, and liver and lung …

Head and neck squamous cell carcinoma (HNSCC) is one of the main malignant tumours
affecting human health, mainly due to delayed diagnosis and high invasiveness …

Ubiquitination is a reversible post-translational modification based on the chemical addition
of ubiquitin to proteins with regulatory effects on various signaling pathways. Ubiquitination …

Exosomes, small yet vital extracellular vesicles, play an integral role in intercellular
communication. They transport critical components, such as proteins, lipid bilayers, DNA …