Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Lineage plasticity, the ability of cells to transition from one committed developmental
pathway to another, has been proposed as a source of intratumoural heterogeneity and of …

Defining the transition from benign to malignant tissue is fundamental to improving early
diagnosis of cancer. Here we use a systematic approach to study spatial genome integrity in …

Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Prostate cancers are considered to be immunologically 'cold'tumors given the very few
patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of …

Despite the success of immune checkpoint blockade against melanoma, many “cold” tumors
like prostate cancer remain unresponsive. We found that hypoxic zones were prevalent …

Nerves closely associate with blood vessels and help to pattern the vasculature during
development. Recent work suggests that newly formed nerve fibers may regulate the tumor …

Cancer cells experience higher oxidative stress from reactive oxygen species (ROS) than do
non-malignant cells because of genetic alterations and abnormal growth; as a result …

During disease progression from primary towards metastatic prostate cancer (PCa), and in
particular bone metastases, the tumor microenvironment (TME) evolves in parallel with the …

The MYC oncogene contributes to the genesis of many human cancers. Recent insights into
its expression and function have led to therapeutic opportunities. MYC's activation by …