An immediate and long-term complication of COVID-19 may be type 2 diabetes mellitus: the central role of β-cell dysfunction, apoptosis and exploration of possible …

MR Hayden - Cells, 2020 - mdpi.com
The novel coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2) was declared a pandemic by the WHO on 19 March …

The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome

K Putnam, R Shoemaker… - American Journal of …, 2012 - journals.physiology.org
The renin-angiotensin system (RAS) is an important therapeutic target in the treatment of
hypertension. Obesity has emerged as a primary contributor to essential hypertension in the …

Potential metabolic and inflammatory pathways between COVID-19 and new-onset diabetes

T Sathish, RJ Tapp, ME Cooper… - Diabetes & …, 2020 - pmc.ncbi.nlm.nih.gov
The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is rapidly evolving worldwide and is now face-to …

Angiotensin‐converting enzyme 2: the first decade

NE Clarke, AJ Turner - International journal of hypertension, 2012 - Wiley Online Library
The renin‐angiotensin system (RAS) is a critical regulator of hypertension, primarily through
the actions of the vasoactive peptide Ang II, which is generated by the action of angiotensin …

Targeting fatty acid metabolism to improve glucose metabolism

R Stinkens, GH Goossens, JWE Jocken… - Obesity …, 2015 - Wiley Online Library
Disturbances in fatty acid metabolism in adipose tissue, liver, skeletal muscle, gut and
pancreas play an important role in the development of insulin resistance, impaired glucose …

Punica granatum flower extract, a potent α-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats

Y Li, S Wen, BP Kota, G Peng, GQ Li… - Journal of …, 2005 - Elsevier
Postprandial hyperglycemia plays an important role in the development of type 2 diabetes
and has been proposed as an independent risk factor for cardiovascular diseases. The …

ACE2 in chronic disease and COVID-19: gene regulation and post-translational modification

CW Wang, HC Chuang, TH Tan - Journal of Biomedical Science, 2023 - Springer
Abstract Angiotensin-converting enzyme 2 (ACE2), a counter regulator of the renin-
angiotensin system, provides protection against several chronic diseases. Besides chronic …

Why blockade of the renin–angiotensin system reduces the incidence of new-onset diabetes

KAM Jandeleit-Dahm, C Tikellis, CM Reid… - Journal of …, 2005 - journals.lww.com
Recent trials have suggested that inhibitors of the renin–angiotensin system (RAS), such as
angiotensin-converting enzyme (ACE) inhibitors and angiotensin II receptor blockers …

The sweeter side of ACE2: physiological evidence for a role in diabetes

SM Bindom, E Lazartigues - Molecular and cellular endocrinology, 2009 - Elsevier
Diabetes mellitus is a growing problem in all parts of the world. Both clinical trials and
animal models of type I and type II diabetes have shown that hyperactivity of angiotensin-II …

Link between the renin–angiotensin system and insulin resistance: Implications for cardiovascular disease

MS Zhou, IH Schulman, Q Zeng - Vascular medicine, 2012 - journals.sagepub.com
The incidence of metabolic syndrome is rapidly increasing in the United States and
worldwide. The metabolic syndrome is a complex metabolic and vascular disorder that is …