The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first
compartment of the secretory pathway. As such, the ER contributes to the production and …

Intracellular α-synuclein (α-syn)-rich protein aggregates called Lewy pathology (LP) and
neuronal death are commonly found in the brains of patients with clinical Parkinson disease …

The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular
infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory …

The cardinal motor symptoms of Parkinson's disease (PD) are caused by the death of
dopaminergic neurons in the substantia nigra pars compacta (SN c). Alpha‐synuclein …

Mitochondria are well appreciated for their role as biosynthetic and bioenergetic organelles.
In the past two decades, mitochondria have emerged as signaling organelles that contribute …

Stress-signaling pathways are evolutionarily conserved and play an important role in the
maintenance of homeostasis. These pathways are also critical for adaptation to new cellular …

Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder that
is characterized by amyloid β-protein deposition in senile plaques, neurofibrillary tangles …

Mitochondria form a highly interconnected tubular network throughout the cell via a dynamic
process, with mitochondrial segments fusing and breaking apart continuously. Strong …

Autophagy is a tightly regulated intracellular bulk degradation/recycling system that has
fundamental roles in cellular homeostasis. Autophagy is initiated by isolation membranes …

The organization and mutual interactions between endoplasmic reticulum (ER) and
mitochondria modulate key aspects of cell pathophysiology. Several proteins have been …