Numerous drug treatments that have recently entered the clinic or clinical trials have their
genesis in zebrafish. Zebrafish are well established for their contribution to developmental …

Nitrogen-containing heterocyclic rings are common structural components of marketed
drugs. Among these heterocycles, imidazole/fused imidazole rings are present in a wide …

Multitargeting compounds comprising activity on more than a single biological target have
gained remarkable relevance in drug discovery owing to the complexity of multifactorial …

Human DNA topoisomerase II is an important target in anticancer therapy. Despite the
clinical success of drugs that target topoisomerase II, the development of resistant cancer …

Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …

Polypharmacology plays an important role in defining response and adverse effects of
drugs. For some mechanisms, experimentally map** polypharmacology is commonplace …

The main challenges in the use of immune checkpoint inhibitors (ICIs) are ascribed to the
immunosuppressive tumor microenvironment and the lack of sufficient infiltration of activated …

Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease”
electing multitarget compounds as potential therapeutic tools suitable for the treatment of …

Targeted drugs and precision medicine have transformed the landscape of cancer therapy
and significantly improved patient outcomes in many cases. However, as therapies are …

In an attempt to extend recent studies showing that some clinically evaluated histamine H3
receptor (H3R) antagonists possess nanomolar affinity at sigma-1 receptors (σ1R), we …