Plant peptides–redefining an area of ribosomally synthesized and post-translationally modified peptides

JR Chekan, LS Mydy, MA Pasquale… - Natural Product …, 2024 - pubs.rsc.org
Covering 1965 to February 2024Plants are prolific peptide chemists and are known to make
thousands of different peptidic molecules. These peptides vary dramatically in their size …

Peptide crosslinking by a class of plant copper enzymes

MROK Noyon, S Hematian - Trends in Chemistry, 2024 - cell.com
BURP domain peptide cyclases, or BpCs (an abbreviation we recommend in this opinion),
are an emerging class of copper enzymes which catalyze the oxidative macrocyclization of …

[HTML][HTML] Characterization of Plant-Growth-Promoting Rhizobacteria for Tea Plant (Camellia sinensis) Development and Soil Nutrient Enrichment

M Wang, H Sun, H Dai, Z Xu - Plants, 2024 - mdpi.com
Plant-growth-promoting rhizobacteria (PGPR) play an important role in plant growth and
rhizosphere soil. In order to evaluate the effects of PGPR strains on tea plant growth and the …

Copper-dependent halogenase catalyses unactivated C− H bond functionalization

CY Chiang, M Ohashi, J Le, PP Chen, Q Zhou, S Qu… - Nature, 2025 - nature.com
Abstract Carbon–hydrogen (C–H) bonds are the foundation of essentially every organic
molecule, making them an ideal place to do chemical synthesis. The key challenge is …

Aromatic side-chain crosslinking in RiPP biosynthesis

SK Kandy, MA Pasquale, JR Chekan - Nature Chemical Biology, 2025 - nature.com
Peptide cyclization is a defining feature of many bioactive molecules, particularly in the
ribosomally synthesized and post-translationally modified peptide (RiPP) family of natural …

Mining raw plant transcriptomic data for new cyclopeptide alkaloids

D Kriger, MA Pasquale, BG Ampolini… - Beilstein Journal of …, 2024 - beilstein-journals.org
In recent years, genome and transcriptome mining have dramatically expanded the rate of
discovering diverse natural products from bacteria and fungi. In plants, this approach is often …

Repurposing Amide Bond-Forming Enzymes for Non-native Protein Modification

T Zhu, B Wu - ACS Catalysis, 2024 - ACS Publications
Site-specific protein modification techniques have led to breakthroughs across diverse
fields, such as cell imaging, proteomics, biomaterials, and pharmaceutical protein and …

α‐N‐Methyltransferase regiospecificity is mediated by proximal, redundant enzyme–substrate interactions

KK Crone, JW Labonte, MH Elias… - Protein …, 2025 - Wiley Online Library
N‐Methylation of the peptide backbone confers pharmacologically beneficial characteristics
to peptides that include greater membrane permeability and resistance to proteolytic …

Subcellular compartmentalized localization of transmembrane proteins essential for production of fungal cyclic peptide cyclochlorotine

T Katayama, Y Jiang, T Ozaki, H Oikawa… - Bioscience …, 2024 - academic.oup.com
Fungal biosynthetic gene clusters often include genes encoding transmembrane proteins,
which have been mostly thought to be transporters exporting the products. However, there is …

The emergence and loss of cyclic peptides in Nicotiana illuminate dynamics and mechanisms of plant metabolic evolution

EM Suh, JK Reinhardt, JK Weng - bioRxiv, 2024 - biorxiv.org
Specialized metabolism plays a central role in how plants cope with both biotic and abiotic
stresses in order to survive and reproduce within dynamic and challenging environments …