Angiogenesis in life, disease and medicine

P Carmeliet - Nature, 2005 - nature.com
The growth of blood vessels (a process known as angiogenesis) is essential for organ
growth and repair. An imbalance in this process contributes to numerous malignant …

Molecular regulation of angiogenesis and lymphangiogenesis

RH Adams, K Alitalo - Nature reviews Molecular cell biology, 2007 - nature.com
Blood vessels and lymphatic vessels form extensive networks that are essential for the
transport of fluids, gases, macromolecules and cells within the large and complex bodies of …

Vascular heterogeneity and specialization in development and disease

M Potente, T Mäkinen - Nature Reviews Molecular Cell Biology, 2017 - nature.com
Blood and lymphatic vessels pervade almost all body tissues and have numerous essential
roles in physiology and disease. The inner lining of these networks is formed by a single …

[HTML][HTML] Lymphangiogenesis: molecular mechanisms and future promise

T Tammela, K Alitalo - Cell, 2010 - cell.com
The growth of lymphatic vessels (lymphangiogenesis) is actively involved in a number of
pathological processes including tissue inflammation and tumor dissemination but is …

The lymphatic vasculature in disease

K Alitalo - Nature medicine, 2011 - nature.com
Blood vessels form a closed circulatory system, whereas lymphatic vessels form a one-way
conduit for tissue fluid and leukocytes. In most vertebrates, the main function of lymphatic …

[HTML][HTML] Lymphatic vessel network structure and physiology

JW Breslin, Y Yang, JP Scallan, RS Sweat… - Comprehensive …, 2018 - ncbi.nlm.nih.gov
The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …

Lymphangiogenesis in development and human disease

K Alitalo, T Tammela, TV Petrova - Nature, 2005 - nature.com
The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues
and returns it to the blood. Lymphatic vessels are also an essential part of the body's …

Lymphatic malformations: genetics, mechanisms and therapeutic strategies

T Mäkinen, LM Boon, M Vikkula, K Alitalo - Circulation research, 2021 - Am Heart Assoc
Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation
interstitial fluid that has extravasated from the blood capillaries. They provide a trafficking …

Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer

H Wiig, MA Swartz - Physiological reviews, 2012 - journals.physiology.org
The interstitium describes the fluid, proteins, solutes, and the extracellular matrix (ECM) that
comprise the cellular microenvironment in tissues. Its alterations are fundamental to …

Functionally specialized junctions between endothelial cells of lymphatic vessels

P Baluk, J Fuxe, H Hashizume, T Romano… - The Journal of …, 2007 - rupress.org
Recirculation of fluid and cells through lymphatic vessels plays a key role in normal tissue
homeostasis, inflammatory diseases, and cancer. Despite recent advances in understanding …