Rational design of immunomodulatory hydrogels for chronic wound healing

M Kharaziha, A Baidya, N Annabi - Advanced Materials, 2021 - Wiley Online Library
With all the advances in tissue engineering for construction of fully functional skin tissue,
complete regeneration of chronic wounds is still challenging. Since immune reaction to the …

Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics

K Zhang, Q Feng, Z Fang, L Gu, L Bian - Chemical Reviews, 2021 - ACS Publications
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

Macrophage phenotypes in tissue repair and the foreign body response: Implications for biomaterial-based regenerative medicine strategies

KE Martin, AJ García - Acta biomaterialia, 2021 - Elsevier
Macrophages are a highly heterogeneous and plastic population of cells that are crucial for
tissue repair and regeneration. This has made macrophages a particularly attractive target …

Immune regulation of skin wound healing: mechanisms and novel therapeutic targets

J Larouche, S Sheoran, K Maruyama… - Advances in wound …, 2018 - liebertpub.com
Significance: The immune system plays a central role in orchestrating the tissue healing
process. Hence, controlling the immune system to promote tissue repair and regeneration is …

Immunopolarization-regulated 3D printed-electrospun fibrous scaffolds for bone regeneration

X Liu, M Chen, J Luo, H Zhao, X Zhou, Q Gu, H Yang… - Biomaterials, 2021 - Elsevier
Abstract Three-dimension (3D)-printed bioscaffolds are precise and personalized for bone
regeneration. However, customized 3D scaffolds may activate the immune response in vivo …

[HTML][HTML] Promoting tissue regeneration by modulating the immune system

Z Julier, AJ Park, PS Briquez, MM Martino - Acta biomaterialia, 2017 - Elsevier
The immune system plays a central role in tissue repair and regeneration. Indeed, the
immune response to tissue injury is crucial in determining the speed and the outcome of the …

A review on the design of hydrogels with different stiffness and their effects on tissue repair

T Luo, B Tan, L Zhu, Y Wang, J Liao - Frontiers in bioengineering and …, 2022 - frontiersin.org
Tissue repair after trauma and infection has always been a difficult problem in regenerative
medicine. Hydrogels have become one of the most important scaffolds for tissue …

Macrophage and fibroblast interactions in biomaterial‐mediated fibrosis

CE Witherel, D Abebayehu, TH Barker… - Advanced healthcare …, 2019 - Wiley Online Library
Biomaterial‐mediated inflammation and fibrosis remain a prominent challenge in designing
materials to support tissue repair and regeneration. Despite the many biomaterial …

Aseptic and septic prosthetic joint loosening: Impact of biomaterial wear on immune cell function, inflammation, and infection

NA Hodges, EM Sussman, JP Stegemann - Biomaterials, 2021 - Elsevier
The success of total joint replacements has led to consistent growth in the use of arthroplasty
in progressively younger patients. However, more than 10 percent of patients require …

Bioactive glass in tissue regeneration: unveiling recent advances in regenerative strategies and applications

Y Zhu, X Zhang, G Chang, S Deng… - Advanced …, 2025 - Wiley Online Library
Bioactive glass (BG) is a class of biocompatible, biodegradable, multifunctional inorganic
glass materials, which is successfully used for orthopedic and dental applications, with …