Current status of autologous stem cell transplantation for multiple myeloma

R Al Hamed, AH Bazarbachi, F Malard… - Blood cancer …, 2019 - nature.com
More than 30 years after its introduction, autologous stem cell transplantation (ASCT)
remains the standard of care for young patients with newly diagnosed multiple myeloma. Not …

International Myeloma Working Group consensus approach to the treatment of multiple myeloma patients who are candidates for autologous stem cell transplantation

M Cavo, SV Rajkumar, A Palumbo… - Blood, The Journal …, 2011 - ashpublications.org
The role of high-dose therapy followed by autologous stem cell transplantation (ASCT) in the
treatment of multiple myeloma (MM) continues to evolve in the novel agent era. The choice …

Autologous transplantation for newly diagnosed multiple myeloma in the era of novel agent induction: a systematic review and meta-analysis

B Dhakal, A Szabo, S Chhabra, M Hamadani… - JAMA …, 2018 - jamanetwork.com
Importance The role of high-dose therapy with melphalan followed by autologous stem cell
transplant (HDT/ASCT) in patients with multiple myeloma continues to be debated in the …

From transplant to novel cellular therapies in multiple myeloma: European Myeloma Network guidelines and future perspectives

F Gay, M Engelhardt, E Terpos, R Wäsch… - …, 2017 - pmc.ncbi.nlm.nih.gov
Survival of myeloma patients has greatly improved with the use of autologous stem cell
transplantation and novel agents, such as proteasome inhibitors, immunomodulatory drugs …

Utilization of hematopoietic stem cell transplantation for the treatment of multiple myeloma: a Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) …

WI Gonsalves, FK Buadi, S Ailawadhi… - Bone marrow …, 2019 - nature.com
Over the last two decades, the utilization of various novel therapies in the upfront or salvage
settings has continued to improve survival outcomes for patients with Multiple Myeloma …

International myeloma working group (IMWG) consensus statement and guidelines regarding the current status of stem cell collection and high-dose therapy for …

S Giralt, EA Stadtmauer, JL Harousseau, A Palumbo… - Leukemia, 2009 - nature.com
Multiple myeloma is the most common indication for high-dose chemotherapy with
autologous stem cell support (ASCT) in North America today. Stem cell procurement for …

A randomized phase 3 study on the effect of thalidomide combined with adriamycin, dexamethasone, and high-dose melphalan, followed by thalidomide maintenance …

HM Lokhorst, B van der Holt… - Blood, The Journal …, 2010 - ashpublications.org
The phase 3 trial HOVON-50 was designed to evaluate the effect of thalidomide during
induction treatment and as maintenance in patients with multiple myeloma who were …

[HTML][HTML] American society of blood and marrow transplantation, european society of blood and marrow transplantation, blood and marrow transplant clinical trials …

S Giralt, L Garderet, B Durie, G Cook, G Gahrton… - Biology of Blood and …, 2015 - Elsevier
In contrast to the upfront setting in which the role of high-dose therapy with autologous
hematopoietic cell transplantation (HCT) as consolidation of a first remission in patients with …

[HTML][HTML] Hematopoietic stem cell transplantation for multiple myeloma: guidelines from the American Society for Blood and Marrow Transplantation

N Shah, N Callander, S Ganguly, Z Gul… - Biology of Blood and …, 2015 - Elsevier
Therapeutic strategies for multiple myeloma (MM) have changed dramatically over the past
decade. Thus, the role of hematopoietic stem cell transplantation (HCT) must be considered …

Inhibition of heat shock protein 90 (HSP90) as a therapeutic strategy for the treatment of myeloma and other cancers

PG Richardson, CS Mitsiades… - British journal of …, 2011 - Wiley Online Library
Summary Heat shock protein 90 (HSP90) is a molecular chaperone that is induced in
response to cellular stress and stabilizes client proteins involved in cell cycle control and …