Acute pain signaling has a key protective role and is highly evolutionarily conserved.
Chronic pain, however, is maladaptive, occurring as a consequence of injury and disease …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Voltage-gated sodium (Nav) channels initiate action potentials in most neurons, including
primary afferent nerve fibres of the pain pathway. Local anaesthetics block pain through non …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect
experienced by cancer patients receiving treatment with paclitaxel. The voltage-gated …

The complete inability to sense pain in an otherwise healthy individual is a very rare
phenotype. In three consanguineous families from northern Pakistan, we mapped the …

Nociception is essential for survival whereas pathological pain is maladaptive and often
unresponsive to pharmacotherapy. Voltage-gated sodium channels, Nav1. 1–Nav1. 9, are …

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …

The third edition of this monograph continues to have the goal of providing an overview of
current thought about the spinal cord mechanisms that are responsible for sensory …

C-type dorsal root ganglion (DRG) neurons can generate tetrodotoxin-resistant (TTX-R)
sodium-dependent action potentials. However, multiple sodium channels are expressed in …

Pain is a sensory state resulting from complex integration of peripheral nociceptive inputs
and central processing. Pain consists of adaptive pain that is acute and beneficial for …