Autophagy is an evolutionarily conserved, lysosome-dependent catabolic process whereby
cytoplasmic components, including damaged organelles, protein aggregates and lipid …

Accumulation of dysfunctional and damaged cellular proteins and organelles occurs during
aging, resulting in a disruption of cellular homeostasis and progressive degeneration and …

Insulin is a critical hormone that promotes energy storage in various tissues, as well as
anabolic functions. Insulin resistance significantly reduces these responses, resulting in …

MicroRNAs (miRNAs) control RNA translation and are a class of small, tissue-specific, non-
protein-coding RNAs that maintain cellular homeostasis through negative gene regulation …

Aging and sedentary life style are considered independent risk factors for many disorders.
Under these conditions, accumulation of dysfunctional and damaged cellular proteins and …

Exercise itself is fundamental for good health, and when practiced regularly confers a myriad
of metabolic benefits in a range of tissues. These benefits are mediated by a range of …

Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent diseases worldwide.
Exercise is a first-line therapy and an important preventive measure for patients with NAFLD …

Lipids droplets (LD) are dynamics organelles that accumulate neutral lipids during nutrient
surplus. LD alternates between periods of growth and consumption through regulated …

Non-alcoholic fatty liver disease (NAFLD) spectrum comprises simple steatosis and non-
alcoholic steatohepatitis (NASH) that can lead to fibrosis and cirrhosis. The patients usually …

Skeletal muscle insulin resistance is known to play an important role in the pathogenesis of
diabetes, and one potential causative cellular mechanism is endoplasmic reticulum (ER) …