Pulmonary drug delivery has the advantages of being rapid, efficient, and well-targeted, with
few systemic side effects. In addition, it is non-invasive and has good patient compliance …

Introduction Drugs for the treatment of respiratory diseases are commonly administered by
oral inhalation. Yet surprisingly little is known about the pulmonary pharmacokinetics of …

Multitarget datasets that correlate bioactivity landscapes of small-molecules toward different
related or unrelated pharmacological targets are crucial for novel drug design and …

Abstract P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are two efflux
transporters which are expressed in the apical (ie airway lumen-facing) membranes of lung …

Background and objectives Suspended respirable airborne particles are associated with
human health risks and especially particles within the range of ultrafine (< 0.1 μm) or fine (< …

In the lungs, the membrane transporter P-glycoprotein (P-gp) is expressed in the apical (ie
lumen-facing) membrane of airway epithelial cells and in the luminal (blood-facing) …

P-glycoprotein (P-gp) is a crucial membrane transporter situated on the cell's apical surface,
being responsible for eliminating xenobiotics and endobiotics. P-gp modulators are …

Intra-articular (IA) administration of drugs for the treatment of diseases such as rheumatoid
arthritis, osteoarthritis and psoriatic arthritis is a common strategy; however, the rapid …

Adenosine triphosphate binding cassette (ABC) transporters are a broad family of
membrane protein complexes that use energy to transport molecules across cells and/or …

A hit-to-lead campaign pursuing the identification of novel inhalant small-molecule
phosphatidylinositol 3-kinase (PI3K) inhibitors for the treatment of inflammatory respiratory …