Toward Microbiome Engineering: expanding the repertoire of genetically tractable members of the human gut Microbiome

JW Marsh, C Kirk, RE Ley - Annual Review of Microbiology, 2023 - annualreviews.org
Genetic manipulation is necessary to interrogate the functions of microbes in their
environments, such as the human gut microbiome. Yet, the vast majority of human gut …

Systems and synthetic biology-driven engineering of live bacterial therapeutics

K Kim, M Kang, BK Cho - Frontiers in Bioengineering and …, 2023 - frontiersin.org
The past decade has seen growing interest in bacterial engineering for therapeutically
relevant applications. While early efforts focused on repurposing genetically tractable model …

Advances in synthetic biology toolboxes paving the way for mechanistic understanding and strain engineering of gut commensal Bacteroides spp. and Clostridium spp …

Y Tan, J Liang, M Lai, S Wan, X Luo, F Li - Biotechnology Advances, 2023 - Elsevier
The gut microbiota plays a significant role in influencing human immunity, metabolism,
development, and behavior by producing a wide range of metabolites. While there is …

Engineering Microbial Consortia as Living Materials: Advances and Prospectives

S Wang, Y Zhan, X Jiang, Y Lai - ACS Synthetic Biology, 2024 - ACS Publications
The field of Engineered Living Materials (ELMs) integrates engineered living organisms into
natural biomaterials to achieve diverse objectives. Multiorganism consortia, prevalent in …

[HTML][HTML] Genome engineering of the human gut microbiome

L Zheng, J Shen, R Chen, Y Hu, W Zhao… - Journal of Genetics and …, 2024 - Elsevier
The human gut microbiome, a complex ecosystem, significantly influences host health,
impacting crucial aspects such as metabolism and immunity. To enhance our …

[HTML][HTML] The most promising next-generation probiotic candidates—impact on Human Health and potential application in Food Technology

P Lalowski, D Zielińska - Fermentation, 2024 - mdpi.com
A substantial body of research indicates that the gut microbiota exerts a profound influence
on host health. The purpose of this work was to characterize selected, most promising, well …

Advancements in gene editing technologies for probiotic-enabled disease therapy

L Wang, J Hu, K Li, Y Zhao, M Zhu - Iscience, 2024 - cell.com
Probiotics typically refer to microorganisms that have been identified for their health benefits,
and they are added to foods or supplements to promote the health of the host. A growing …

[HTML][HTML] EcoGenoRisk: Develo** a computational ecological risk assessment tool for synthetic biology

A Ulanova, C Mansfeldt - Environmental Pollution, 2024 - Elsevier
The expanding field of synthetic biology (synbio) supports new opportunities in the design of
targeted bioproducts or modified microorganisms. However, this rapid development of …

A Nitrate/Nitrite Biosensor Designed with an Antiterminator for In Vivo Diagnosis of Colitis Based on Bacteroides thetaiotaomicron

X Yang, M Ye, F Wang, X Yang, X Gao, J Yu… - ACS Synthetic …, 2025 - ACS Publications
Bacteroides thetaiotaomicron is a common microorganism in the human gut that has been
linked to health benefits. Furthermore, it is an emerging synthetic biology chassis with the …

Research and application of intelligent diagnosis and treatment engineering bacteria

N Zhao, J Chen, J Shi, Y Gao, L Li… - … in Bioengineering and …, 2024 - frontiersin.org
For over a century, scientists have been harnessing the therapeutic potential of bacteria in
treating diseases. The advent of synthetic biology in recent years has propelled the …