The zebrafish is an excellent model system for studying the molecular basis of inner ear
development and function. The eggs develop ex utero and the ear is transparent for the first …

Abstract Recent years have seen a renaissance of investigation into the mechanisms of
inner ear development. Genetic analysis of zebrafish has contributed significantly to this …

We describe a novel mechanism for vital fluorescent dye entry into sensory cells and
neurons: permeation through ion channels. In addition to the slow conventional uptake of …

Hair cells in mouse cochlear cultures are selectively labeled by brief exposure to FM1-43, a
styryl dye used to study endocytosis and exocytosis. Real-time confocal microscopy …

Sensorineural hearing loss is genetically heterogeneous. Here, we report that mutations in
CIB2, which encodes a calcium-and integrin-binding protein, are associated with …

Abstract oskar messenger RNA localization at the posterior pole of the Drosophila oocyte is
essential for germline and abdomen formation in the future embryo,. The nuclear shuttling …

Hair cells detect sound and movement and transmit this information via specialized ribbon
synapses. Here we report that asteroid, a gene identified in an ethylnitrosourea mutagenesis …

The senses of hearing and balance in vertebrates rely on the sensory hair cells (HCs) of the
inner ear. The central element of the HC's transduction apparatus is a mechanically gated …

Hair cells have highly organized bundles of apical projections, or stereocilia, that are
deflected by sound and movement. Displacement of stereocilia stretches linkages at the tips …

Mechanosensory hair cells within the zebrafish lateral line spontaneously regenerate after
aminoglycoside-induced death. Exposure of 5-d-old larvae to 400 μm neomycin for 1 h …