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Computational Investigation of Coaggregation and Cross-Seeding between Aβ and hIAPP Underpinning the Cross-Talk in Alzheimer's Disease and Type 2 Diabetes
The coexistence of amyloid-β (Aβ) and human islet amyloid polypeptide (hIAPP) in the brain
and pancreas is associated with an increased risk of Alzheimer's disease (AD) and type 2 …
and pancreas is associated with an increased risk of Alzheimer's disease (AD) and type 2 …
Computational insights into the cross-talk between medin and Aβ: implications for age-related vascular risk factors in Alzheimer's disease
The aggregation of medin forming aortic medial amyloid is linked to arterial wall
degeneration and cerebrovascular dysfunction. Elevated levels of arteriolar medin are …
degeneration and cerebrovascular dysfunction. Elevated levels of arteriolar medin are …
Molecular insights into the effects of F16L and F19L substitutions on the conformation and aggregation dynamics of human calcitonin
Human calcitonin (hCT) regulates calcium–phosphorus metabolism, but its amyloid
aggregation disrupts physiological activity, increases thyroid carcinoma risk, and hampers …
aggregation disrupts physiological activity, increases thyroid carcinoma risk, and hampers …
Deciphering the morphological difference of Amyloid-β fibrils in familial and sporadic Alzheimer's diseases
The aggregation of amyloid-β (Aβ) into amyloid fibrils is the major pathological hallmark of
Alzheimer's disease (AD). Aβ fibrils can adopt a variety of morphologies, the relative …
Alzheimer's disease (AD). Aβ fibrils can adopt a variety of morphologies, the relative …
Computational insights into the aggregation mechanism and amyloidogenic core of aortic amyloid medin polypeptide
Medin amyloid, prevalent in the vessel walls of 97% of individuals over 50, contributes to
arterial stiffening and cerebrovascular dysfunction, yet our understanding of its aggregation …
arterial stiffening and cerebrovascular dysfunction, yet our understanding of its aggregation …
Computational insights into the aggregation mechanism of human calcitonin
Human calcitonin (hCT) is a peptide hormone that regulates calcium homeostasis, but its
abnormal aggregation can disrupt physiological functions and increase the risk of medullary …
abnormal aggregation can disrupt physiological functions and increase the risk of medullary …