The development of the mammary gland is unique: the final stages of development occur
postnatally at puberty under the influence of hormonal cues. Furthermore, during the life of …

The microenvironment influences gene expression so that the behavior of a cell is largely
determined by its interactions with the extracellular matrix, neighboring cells, and soluble …

During carcinogenesis of pancreatic islets in transgenic mice, an angiogenic switch
activates the quiescent vasculature. Paradoxically, vascular endothelial growth factor …

Programmed cell death (PCD) or apoptosis is a naturally occurring cell suicide pathway
induced in a variety of cell types. In many cases, PCD is induced by the withdrawal of …

The matrix metalloproteinase MMP-9/gelatinase B is upregulated in angiogenic dysplasias
and invasive cancers of the epidermis in a mouse model of multi-stage tumorigenesis …

Expression of HPV16 early region genes in basal keratinocytes of transgenic mice elicits a
multistage pathway to squamous carcinoma. We report that infiltration by mast cells and …

The determination of animal form depends on the coordination of events that lead to the
morphological patterning of cells. This epigenetic view of development suggests that …

The matrix‐degrading metalloproteinases are an intriguing family of enzymes that have
evolved to digest specific extracellular matrix components. The expression of these enzymes …

Apoptosis (programmed cell death) plays a major role in development and tissue
regeneration. Basement membrane extracellular matrix (ECM), but not fibronectin or …

Pregnancy-associated breast cancer, which has a poor prognosis, is often overlooked by
clinicians and researchers alike. With the trend towards delayed child-bearing, an increase …