Role of oxidative stress in the pathogenesis of non-alcoholic fatty liver disease: implications for prevention and therapy

JC Arroyave-Ospina, Z Wu, Y Geng, H Moshage - Antioxidants, 2021‏ - mdpi.com
Oxidative stress (OxS) is considered a major factor in the pathophysiology of inflammatory
chronic liver diseases, including non-alcoholic liver disease (NAFLD). Chronic impairment of …

[HTML][HTML] CYP2E1 in alcoholic and non-alcoholic liver injury. Roles of ROS, reactive intermediates and lipid overload

R Harjumäki, CS Pridgeon… - International journal of …, 2021‏ - mdpi.com
CYP2E1 is one of the fifty-seven cytochrome P450 genes in the human genome and is
highly conserved. CYP2E1 is a unique P450 enzyme because its heme iron is constitutively …

The Asian Pacific Association for the Study of the Liver clinical practice guidelines for the diagnosis and management of metabolic associated fatty liver disease

M Eslam, SK Sarin, VWS Wong, JG Fan… - Hepatology …, 2020‏ - Springer
Metabolic associated fatty liver disease (MAFLD) is the principal worldwide cause of liver
disease and affects nearly a quarter of the global population. The objective of this work was …

Epidemiology, pathogenesis, diagnosis and emerging treatment of nonalcoholic fatty liver disease

E Makri, A Goulas, SA Polyzos - Archives of medical research, 2021‏ - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with an
estimated rising prevalence, in concert with the epidemics of obesity and type 2 diabetes …

[HTML][HTML] Current options and future directions for NAFLD and NASH treatment

C Zhang, M Yang - International Journal of Molecular Sciences, 2021‏ - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, with a broad spectrum ranging from simple steatosis to advanced stage of …

[HTML][HTML] Non-alcoholic fatty liver disease in women–Current knowledge and emerging concepts

PC Eng, R Forlano, T Tan, P Manousou, WS Dhillo… - JHEP Reports, 2023‏ - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a major cause of liver disease worldwide,
affecting up to 30% of adults. Progression to non-alcoholic steatohepatitis (NASH) is a key …

[HTML][HTML] Vitamin E beyond its antioxidant label

A Ungurianu, A Zanfirescu, G Nițulescu, D Margină - Antioxidants, 2021‏ - mdpi.com
Vitamin E, comprising tocopherols and tocotrienols, is mainly known as an antioxidant. The
aim of this review is to summarize the molecular mechanisms and signaling pathways linked …

[HTML][HTML] Mitochondrial dysfunction in metabolic dysfunction fatty liver disease (MAFLD)

Y Zhao, Y Zhou, D Wang, Z Huang, X **ao… - International Journal of …, 2023‏ - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) has become an increasingly common disease in
Western countries and has become the major cause of liver cirrhosis or hepatocellular …

[HTML][HTML] The effect of vitamin E supplementation on serum aminotransferases in non-alcoholic fatty liver disease (NAFLD): A systematic review and meta-analysis

S Vogli, A Naska, G Marinos, MI Kasdagli, P Orfanos - Nutrients, 2023‏ - mdpi.com
Νon-alcoholic fatty liver disease (NAFLD) is a common cause of end-stage liver disease in
developed countries. Oxidative stress plays a key role during the course of the disease and …

Non-alcoholic fatty liver disease and childhood obesity

M Shaunak, CD Byrne, N Davis, P Afolabi… - Archives of disease in …, 2021‏ - adc.bmj.com
Non-alcoholic fatty liver disease (NAFLD) in children and adolescents has an estimated
prevalence of 36.1% in the context of obesity. This figure is anticipated to increase in …