Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, both at the molecular
and histological level. High-throughput sequencing and gene expression profiling have …

The pathogenesis of hepatocellular carcinoma (HCC) is poorly understood, but recent
advances in genomics have increased our understanding of the mechanisms by which …

Background & Aims Our increasing understanding of hepatocellular carcinoma (HCC)
biology holds promise for personalized care, however its translation into clinical practice …

Immune cells constitute an important element of tumor tissue. Accumulating evidence
indicates their clinicopathological significance in predicting prognosis and therapeutic …

The incidence of hepatocellular carcinoma (HCC) is rapidly increasing due to the
prevalence of obesity and non-alcoholic fatty liver disease, but the molecular triggers that …

Objective To assess the value of qualitative and quantitative MRI radiomics features for
noninvasive prediction of immuno-oncologic characteristics and outcomes of hepatocellular …

Background & Aims Despite the clinical and genetic significance of macrotrabecular-
massive hepatocellular carcinoma (MTM-HCC), its characteristics on imaging have not been …

Introduction: Although immune checkpoint inhibitors (ICIs) have been considered as
promising agents for the treatment of advanced hepatocellular carcinoma (HCC), previous …

Activation of the Hippo pathway effector Yap underlies many liver cancers, however no
germline or somatic mutations have been identified. Autophagy maintains essential …

The liver is a major store of glycogen and is essential in maintaining systemic glucose
homeostasis. In healthy individuals, glycogen synthesis and breakdown in the liver are …