As the most commonly occurring cancer in women worldwide, breast cancer poses a
formidable public health challenge on a global scale. Breast cancer consists of a group of …

There are well-established disparities in cancer incidence and outcomes by race/ethnicity
that result from the interplay between structural, socioeconomic, socio-environmental …

Pancreatic ductal adenocarcinoma is most frequently detected at an advanced stage. Such
late detection restricts treatment options and contributes to a dismal 5-year survival rate of 3 …

The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …

The BRCA Challenge is a long-term data-sharing project initiated within the Global Alliance
for Genomics and Health (GA4GH) to aggregate BRCA1 and BRCA2 data to support highly …

Genome-wide association studies have identified> 10,000 genetic variants associated with
various phenotypes and diseases. Although the majority are common variants, rare variants …

Genetic diversity of germline variants in breast cancer (BC) predisposition genes is
unexplored in miscegenated populations, such those living in Latin America. We evaluated …

Importance During the past few decades, the incidence of breast cancer (BC) has been
increasing rapidly in East Asia, and BC is currently the most common cancer in several …

Background Pathogenic variants in BRCA1 and BRCA2 (BRCA1/2) lead to increased risk of
breast, ovarian, and other cancers, but most variant-positive individuals in the general …

Direct-to-consumer (DTC) genetic tests are sold online and in shops as a way to “find out
what your DNA says.” 1 2 Testing kits typically contain instructions and equipment for …